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The role of dexamethasone in the treatment of bacterial meningitis - a systematic review

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  1. Inadequate emergence after non-cardiac surgery-A prospective observational study in 1000 patients

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  2. Time to onset of gastrointestinal bleeding in the SUP-ICU trial: a preplanned substudy

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  3. Heterogeneity of treatment effect of stress ulcer prophylaxis in ICU patients: A secondary analysis protocol

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  4. Pantoprazole in ICU patients at risk for gastrointestinal bleeding-1-year mortality in the SUP-ICU trial

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  5. Storage time of red blood cells among ICU patients with septic shock

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  1. Delirium assessment in neuro-critically ill patients: A validation study

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  2. Comparison of methods for measuring antibiotic consumption in an intensive care unit

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  3. Reply to "Normal range for cytokines should be reported"

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Corticosteroids are used as an adjunct to antibiotics in the treatment of bacterial meningitis in an attempt to attenuate the intrathecal inflammatory response and thereby reduce mortality and morbidity. The purpose of the present paper is to provide a review of clinical studies of corticosteroids in the treatment of bacterial meningitis. Relevant literature was found in PubMed, the Cochrane databases, and references in studies. Forty-four publications of relevance were identified, comprising 29 publications of randomised studies, 10 publications reporting either non- or quasi-randomised studies, and five reporting retrospective studies, and nine meta-analyses. Taken together, dexamethasone treatment may be associated with a lower mortality in adults and fewer neurological and auditory sequelae in adults and children from high-income countries, in particular in adults suffering from pneumococcal meningitis. In contrast, studies conducted in developing countries have yielded less favourable results.
Original languageEnglish
JournalActa Anaesthesiologica Scandinavica
Volume56
Issue number10
Pages (from-to)1210-21
Number of pages12
ISSN0001-5172
DOIs
Publication statusPublished - 2012

ID: 36494078