Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

The role of blood volume in cardiac dysfunction and reduced exercise tolerance in patients with diabetes

Research output: Contribution to journalReviewpeer-review

  1. Induction of erythroferrone in healthy humans by micro-dose recombinant erythropoietin or high-altitude exposure

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The interaction between metformin and physical activity on postprandial glucose and glucose kinetics: a randomised, clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Intravascular volumes evaluated by a carbon monoxide rebreathing method in patients undergoing chronic hemodialysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Did you know-why does maximal oxygen uptake increase in humans following endurance exercise training?

    Research output: Contribution to journalEditorialpeer-review

  5. Transcerebral exchange kinetics of large neutral amino acids during acute inspiratory hypoxia in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Blood volume is an integral component of the cardiovascular system, and fundamental to discerning the pathophysiology of multiple cardiovascular conditions leading to exercise intolerance. Based on a systematic search of controlled studies assessing blood volume, in this Personal View we describe how hypovolaemia is a prevalent characteristic of patients with diabetes, irrespective of sex, age, and physical activity levels. Multiple endocrine and haematological mechanisms contribute to hypovolaemia in diabetes. The regulation of intravascular volumes is altered by sustained hyperglycaemia and hypertension. Chronic activation of endocrine systems controlling fluid homeostasis, such as the renin-angiotensin-aldosterone system and vasopressin axis, has a role in progressive kidney desensitisation and diabetic nephropathy. Furthermore, albumin loss from the intravascular compartment reduces the osmotic potential of plasma to retain water. Hypovolaemia also affects the loading conditions and filling of the heart in diabetes. The elucidation of modifiable volumetric traits will plausibly have major health benefits in the diabetes population.

Original languageEnglish
JournalThe Lancet Diabetes and Endocrinology
Issue number10
Pages (from-to)807-816
Number of pages10
Publication statusPublished - Oct 2019

ID: 59267819