Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The Role of Angiotensin-Converting Enzyme Inhibitors in Patients with Chronic Subdural Hematoma: A Scandinavian Population-Based Multicenter Study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Deciding on Appropriate Telemetric Intracranial Pressure Monitoring System

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Snaring of a Glued Microcatheter During Embolization of an Arteriovenous Malformation with N-Butyl Cyanoacrylate

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Intracranial Pressure: A Comparison of the Noninvasive HeadSense Monitor versus Lumbar Pressure Measurement

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Cerebellar Mutism Syndrome and Other Complications After Surgery in the Posterior Fossa in Adults: A Prospective Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Stereotactic Brain Biopsy in Eloquent Areas Assisted by Navigated Transcranial Magnetic Stimulation: a Technical Case Report

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Amino acid tracers in PET imaging of diffuse low-grade gliomas: a systematic review of preoperative applications

    Research output: Contribution to journalReviewResearchpeer-review

  3. Identification of neoepitopes recognized by tumor-infiltrating lymphocytes (TILs) from patients with glioma

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Jiri Bartek
  • Kristin Sjåvik
  • Samuel Schaible
  • Sasha Gulati
  • Ole Solheim
  • Petter Förander
  • Asgeir Store Jakola
View graph of relations

OBJECTIVE: To investigate the role of angiotensin converting enzyme (ACE) inhibitors in the recurrence of chronic subdural hematoma (cSDH) after burr hole surgery.

METHODS: A retrospective review was conducted of a Scandinavian multicenter, population-based cohort of 1252 adults with cSDH who underwent with burr hole surgery between January 1, 2005, and December 31, 2010. The risk of cSDH recurrence was assessed in users of ACE inhibitors, users of angiotensin II receptor blockers (ARBs), and those without ACE inhibitor treatment (no ACE inhibitor group) using univariable and multivariable regression analyses.

RESULTS: The cohort included 98 (7.8%) ACE inhibitor users and 63 (5%) ARB-only users. The recurrence rate was 16.3% (n = 16) in the ACE inhibitor group, compared with 13.3% (n = 153) in the no ACE inhibitor group (P = 0.39) and 14.3% (n = 9) in the ARB group (P = 0.73). When comparing groups, age (P = 0.01), Charlson Comorbidity Index (P = 0.01), use of platelet inhibitors (P = 0.001) and use of anticoagulants (P = 0.01) differed between the ACE inhibitor and no ACE inhibitor groups. Only age differed significantly between the ACE inhibitor and ARB groups (P = 0.03). In the analyses adjusted for differences in baseline characteristics, ACE inhibitor treatment did not influence the risk of recurrence (odds ratio, 1.2; 95% confidence interval, 0.7-2.2; P = 0.46).

CONCLUSION: In this population-based study, the use of ACE inhibitors was not associated with the risk of recurrence following burr hole surgery for cSDH.

Original languageEnglish
JournalWorld Neurosurgery
Volume113
Pages (from-to)e555-e560
ISSN1878-8750
DOIs
Publication statusPublished - May 2018

    Research areas

  • Aged, Aged, 80 and over, Angiotensin-Converting Enzyme Inhibitors/therapeutic use, Cohort Studies, Female, Hematoma, Subdural, Chronic/diagnosis, Humans, Male, Middle Aged, Population Surveillance/methods, Recurrence, Retrospective Studies, Scandinavian and Nordic Countries/epidemiology

ID: 55800726