Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The risk of fractures, acute myocardial infarction, atrial fibrillation and ventricular arrhythmia in geriatric patients exposed to promethazine

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Strategies to counter antipsychotic-associated weight gain in patients with schizophrenia

    Research output: Contribution to journalReviewpeer-review

  2. An update on the drug safety of treating erectile dysfunction

    Research output: Contribution to journalReviewpeer-review

  3. Cardiovascular safety and benefits of GLP-1 receptor agonists

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Male fertility before and after androgen abuse

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Systemisk toksicitet ved lokalanalgetika

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. High-Dose Glucagon Has Hemodynamic Effects Regardless of Cardiac Beta-Adrenoceptor Blockade: A Randomized Clinical Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Active chlordiazepoxide metabolites in a patient needing life support after treatment of alcohol abstinence

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Smartphone App to Self-Monitor Nausea During Pediatric Chemotherapy Treatment: User-Centered Design Process

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Objectives: This study aimed to compare the risk of fractures, acute myocardial infarction, atrial fibrillation, and ventricular arrhythmia among Danish citizens aged ≥ 65 which were new users of promethazine or domperidone, triazolam, loratadine, and betahistine. Secondly, the study aimed to perform a risk stratification to identify the most relevant predictors for the study outcomes.Methods: The study period was 01/01/2015 to 31/12/2016. The data sources were the Danish registers. Each patient was followed for 90 days. A logistic regression model was used to compute the unadjusted and adjusted odds ratios (OR), and a conditional inference tree was used to identify the most relevant predictors for the study outcomes.Results: Promethazine had a higher risk of hospitalization for atrial fibrillation than loratadine and betahistine (OR 1.58; 95% CI 1.07-2.63 and OR 3.22; 95% CI 1.69-7.14, respectively). For fractures, acute myocardial infarction, and ventricular arrhythmia hospitalizations, no statistically significant differences were found among drugs under investigation. The medical history of cardiac arrhythmia (OR 4.14; 95% CI 2.94-5.78, p<0.0001) was the most relevant predictor for atrial fibrillation hospitalizations.Conclusion: This study found an increased risk of atrial fibrillation hospitalization among promethazine users, and the risk was higher among patients with prior cardiac arrhythmia.

Original languageEnglish
JournalExpert Opinion on Drug Safety
Volume19
Issue number3
Pages (from-to)349-357
Number of pages9
ISSN1474-0338
DOIs
Publication statusPublished - Mar 2020

    Research areas

  • artificial intelligence, beers criteria, cohort study, drug safety, Geriatric patients, machine learning, nationwide, promethazine

ID: 58933451