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The relationship between some beta-adrenergic mediated responses and plasma concentrations of adrenaline and cyclic AMP in man

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  • E K Philipsen
  • John Gabriel Myhre
  • S Larsen
  • M Damkjaer Nielsen
  • Janett Holst
  • J Hilsted
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To test the hypothesis that increments in plasma cyclic AMP during beta-adrenergic stimulation reflect integrated second messenger function of the tissues activated by the agonist, graded adrenaline infusion resulting in plasma adrenaline concentrations within the physiological range was performed in 8 healthy subjects with and without concomitant beta-adrenoceptor blockade by iv propranolol. A significant correlation was found between increments in plasma adrenaline and plasma cyclic AMP in the experiments without beta-blockade; during concomitant beta-blockade the increase in plasma cyclic AMP concentrations at low adrenaline infusion rates was prevented, whereas a small increase in cyclic AMP was found at high adrenaline infusion rates, probably owing to incomplete beta-receptor blockade. Likewise, the adrenaline-induced increments in blood substrates (glucose, lactate, glycerol and beta hydroxybutyric acid) were significantly reduced but not completely prevented by beta-blockade. We conclude that an altered relationship between beta-agonist concentrations and plasma cyclic AMP may provide evidence for the existence of differences in beta-adrenergic sensitivity in man.
Original languageEnglish
JournalActa Endocrinologica (Copenh)
Volume122
Issue number1
Pages (from-to)115-20
Number of pages6
ISSN0001-5598
Publication statusPublished - Jan 1990
Externally publishedYes

    Research areas

  • Adrenergic beta-Antagonists, Adult, Blood Pressure, Catecholamines, Cyclic AMP, Epinephrine, Glucagon, Heart Rate, Humans, Infusions, Intravenous, Insulin, Intestines, Male, Pancreas, Propranolol, Receptors, Adrenergic, beta

ID: 40238258