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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The relation of germ cells per tubule in testes, serum inhibin B and FSH in cryptorchid boys

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  1. Gonocyte transformation in congenital undescended testes: what is the role of inhibin-B in cell death?

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  2. Is infertility after surgery for cryptorchidism congenital or acquired?

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  3. The incidence of maldescended testes in Denmark

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  1. Newborn body composition after maternal bariatric surgery

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  2. Recurrence and survival rates in node negative patients after sentinel node biopsy for early-stage vulva cancer - A nationwide study

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At bilateral orchiopexy bilateral biopsies may be indicated to determine fertility potential. It is currently unknown if the serum inhibin B levels at time of orchiopexy reflect the testicular status of the bilaterally cryptorchid child. The aim of this study was to relate the results of inhibin B and FSH measurements with testicular biopsy parameters in bilateral cryptorchid boys. Included were 25 boys with bilateral cryptorchidism, median 2.5 years (9 months to 5.5 years) at surgery for bilateral cryptorchidism with simultaneous testicular biopsies, and blood sample for inhibin B and FSH. The number of spermatogonia and gonocytes was measured in 100 tubular transverse sections, the S/T and the mean-S/T of the patient was found, and expressed as percent of lowest normal value. Inhibin B and FSH were measured and related to age-specific values. Forty percent (10/25) of the patients had very low mean-S/T (mean-S/T<10% of lowest normal-value). Inhibin B was decreased in 24% (6/25) of the patients, all with decreased mean-S/T, predominantly with a mean-S/T<10% of lowest normal-value (p<0.05). There was a negative correlation between inhibin B and FSH (p<0.05). In cases of mean-S/T<10% of lowest normal-value and decreased inhibin B, we found increased FSH in 9% (2/22) of the patients and hypergonadotropic hypogonadism was suspected. Low FSH was found in 5% (1/22) of the patients and hypogonadotropic hypogonadism was suspected. Low inhibin B predicts a serious condition in respect of infertility. Low FSH and inhibin B indicates examination for hypogonadotropic hypogonadism. In bilateral cryptorchid boys inhibin B levels correlated negatively to FSH.

Original languageEnglish
JournalPediatric Surgery International
Volume23
Issue number2
Pages (from-to)163-9
Number of pages7
ISSN0179-0358
DOIs
Publication statusPublished - Feb 2007

    Research areas

  • Child, Preschool, Cryptorchidism, Follicle Stimulating Hormone, Humans, Infant, Inhibins, Male, Seminiferous Tubules, Sperm Count, Spermatozoa

ID: 46508988