Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The Relation between Red Meat and Whole-Grain Intake and the Colonic Mucosal Barrier: A Cross-Sectional Study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Familial associations in hair cortisol concentration: A cross-sectional analysis based on the Healthy Start study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Vitamin D and Calcium Milk Fortification in Pregnant Women with Periodontitis: A Feasibility Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Mohamad Jawhara
  • Signe Bek Sørensen
  • Berit Lilienthal Heitmann
  • Þórhallur Ingi Halldórsson
  • Andreas Kristian Pedersen
  • Vibeke Andersen
View graph of relations

The Colonic Mucosal Barrier (CMB) is the site of interaction between the human body and the colonic microbiota. The mucus is the outer part of the CMB and is considered as the front-line defense of the colon. It separates the host epithelial lining from the colonic content, and it has previously been linked to health and diseases. In this study, we assessed the relationship between red meat and whole-grain intake and (1) the thickness of the colonic mucus (2) the expression of the predominant mucin gene in the human colon (MUC2). Patients referred to colonoscopy at the University Hospital of Southern Denmark- Sonderjylland were enrolled between June 2017 and December 2018, and lifestyle data was collected in a cross-sectional study design. Colonic biopsies, blood, urine, and fecal samples were collected. The colonic mucus and bacteria were visualized by immunostaining and fluorescence in situ hybridization techniques. We found a thinner mucus was associated with high red meat intake. Similarly, the results suggested a thinner mucus was associated with high whole-grain intake, albeit to a lesser extent than red meat. This is the first study assessing the association between red meat and whole-grain intake and the colonic mucus in humans. This study is approved by the Danish Ethics Committee (S-20160124) and the Danish Data Protecting Agency (2008-58-035). A study protocol was registered at clinical trials.gov under NCT04235348.

Original languageEnglish
JournalNutrients
Volume12
Issue number6
ISSN2072-6643
DOIs
Publication statusPublished - 12 Jun 2020

ID: 61194775