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The Capital Region of Denmark - a part of Copenhagen University Hospital

The rate of accumulation of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in patients kept on a virologically failing regimen containing an NNRTI*

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Virological failure of first-generation nonnucleoside reverse transcriptase inhibitors (NNRTIs) can compromise the efficacy of etravirine as a result of the accumulation of NNRTI resistance mutations. How quickly NNRTI resistance accumulates in patients with a delayed switch from nevirapine or efavirenz despite virological failure, when these drugs are used as a component of combination antiretroviral therapy (cART), remains unclear.
Original languageEnglish
JournalHIV Medicine
Issue number1
Pages (from-to)62-72
Number of pages11
Publication statusPublished - 2012

    Research areas

  • Adult, Aged, Anti-HIV Agents, Benzoxazines, DNA Mutational Analysis, Drug Resistance, Viral, Female, HIV Infections, Humans, Male, Middle Aged, Mutation, Nevirapine, Prospective Studies, Reverse Transcriptase Inhibitors, Viral Load, Young Adult

ID: 36457275