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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The PTPN22 C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes

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The protein tyrosine phosphatase nonreceptor type 2 (PTPN22) has been established as a type 1 diabetes susceptibility gene. A recent study found the C1858T variant of this gene to be associated with lower residual fasting C-peptide levels and poorer glycemic control in patients with type 1 diabetes. We investigated the association of the C1858T variant with residual beta-cell function (as assessed by stimulated C-peptide, proinsulin and insulin dose-adjusted HbA1c), glycemic control, daily insulin requirements, diabetic ketoacidosis (DKA) and diabetes-related autoantibodies (IA-2A, GADA, ICA, ZnT8Ab) in children during the first year after diagnosis of type 1 diabetes.
Original languageEnglish
JournalB M C Medical Genetics
Volume12
Pages (from-to)41
ISSN1471-2350
DOIs
Publication statusPublished - 2011

    Research areas

  • Autoantibodies, C-Peptide, Child, Cohort Studies, Diabetes Mellitus, Type 1, Diabetic Ketoacidosis, Enzyme-Linked Immunosorbent Assay, Female, Genetic Predisposition to Disease, Humans, Male, Polymorphism, Single Nucleotide, Proinsulin, Protein Tyrosine Phosphatase, Non-Receptor Type 22, Regression Analysis, Time Factors

ID: 34668209