Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The prolactin releasing effect of histamine is unrelated to its vascular action

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Urinary growth hormone excretion in acromegaly: diagnostic value in mild disease activity

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Impaired pancreatic polypeptide response to a meal in type 1 diabetic patients: vagal neuropathy or islet cell dysfunction?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Bone metabolism in obesity: changes related to severe overweight and dietary weight reduction.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Effects of thyrotropin-releasing hormone on regional cerebral blood flow in man

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Limited diagnostic utility of Chromogranin A measurements in workup of neuroendocrine tumors

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. True Chromogranin A concentrations in plasma from patients with small intestinal neuroendocrine tumours

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

We investigated in male rats whether the prolactin releasing effect of systemically infused histamine might be attributed to a vasodilatatory action of the compound. Intraarterial infusion of histamine (3.8 mumol) over 1 min increased the plasma PRL 10-fold. This effect was prevented by prior ia infusion of the H1 receptor antagonist mepyramine and slightly augmented by prior ia infusion of the H2 receptor antagonist cimetidine. At the same time histamine caused an immediate 38% decrease in mean arterial blood pressure, which remained 15% below the initial level during the rest of the 60-min observation period. The depressor effect of histamine was prevented by pretreatment with mepyramine and partly prevented for the first 5 min by pretreatment with cimetidine. Since the H1 receptor seemed to be the predominant mediator of the histamine-induced hypotension and PRL release, a causative interaction is possible. However, when the histamine-induced decrease in blood pressure was prevented by simultaneous iv loading with saline the PRL response to histamine was still evident. Furthermore, when the histamine-induced decrease in blood pressure was mimicked by ia infusion of the vasodilator nitroprusside no effect was observed on PRL secretion. We conclude that the histamine-induced stimulation of PRL secretion is independent of the profound depressor action of the amine.

Original languageEnglish
JournalActa Endocrinologica
Volume122
Issue number1
Pages (from-to)49-54
Number of pages6
ISSN0001-5598
Publication statusPublished - Jan 1990

    Research areas

  • Animals, Blood Pressure/drug effects, Histamine/administration & dosage, Hypotension/chemically induced, Infusions, Intravenous, Male, Nitroprusside/administration & dosage, Prolactin/blood, Rats, Rats, Inbred Strains, Vascular Resistance/drug effects

ID: 55078765