TY - JOUR
T1 - The prevention of adverse pregnancy outcomes by periodontal treatment during pregnancy (PROBE) intervention study-A controlled intervention study
T2 - Protocol paper
AU - Winckler, Karoline
AU - Bukkehave, Kathrine Hansen
AU - Tarnow, Lise
AU - Iversen, Peter Bindslev
AU - Damgaard, Christian
AU - Ditlev, Sisse Bolm
AU - Kofoed-Enevoldsen, Allan
AU - Fischer, Heidi Marianne
AU - Dueholm, Signe Camilla Hjuler
AU - Lauenborg, Jeannet
AU - Trier, Cæcilie
AU - Heitmann, Berit Lilienthal
N1 - Publisher Copyright:
© 2024 Public Library of Science. All rights reserved.
PY - 2024/5
Y1 - 2024/5
N2 - INTRODUCTION: Pregnancy increases the risk of periodontitis due to the increase in progesterone and estrogen. Moreover, periodontitis during pregnancy is associated with development of pregnancy and birth related complications. The aim of this study is to determine, whether periodontal treatment during pregnancy can reduce systemic inflammation and lower the risk of adverse pregnancy and birth related outcomes.METHODS AND ANALYSIS: The PROBE study is a non-randomized controlled intervention study conducted among 600 pregnant women with periodontitis. The women will be recruited among all pregnant women at two Danish hospitals in Region Zealand during their nuchal translucency scan and will subsequently be screened for periodontitis. The intervention group includes 300 pregnant women, who will be offered state-of-the-art periodontal treatment during pregnancy. The control group includes additional 300 pregnant women, who will be offered periodontal treatment after giving birth. Outcome measures include periodontal measures, inflammatory, hormonal and glycaemic markers as well as the prevalence of preterm birth risk, low birth weight and risk markers of gestational diabetes mellitus (GDM) and preeclampsia that will be collected from all screened women and further during pregnancy week 20 and pregnancy week 35 for women enrolled in the intervention.ETHICS AND DISSEMINATION: The study's findings will be published in peer reviewed journals and disseminated at national and international conferences and through social media. The PROBE study is designed to provide important new knowledge as to whether periodontal treatment during pregnancy can reduce the prevalence of complications related to pregnancy and birth.CLINICAL TRIALS REGISTRATION: The study was registered on clinicaltrials.gov (NCT06110143).
AB - INTRODUCTION: Pregnancy increases the risk of periodontitis due to the increase in progesterone and estrogen. Moreover, periodontitis during pregnancy is associated with development of pregnancy and birth related complications. The aim of this study is to determine, whether periodontal treatment during pregnancy can reduce systemic inflammation and lower the risk of adverse pregnancy and birth related outcomes.METHODS AND ANALYSIS: The PROBE study is a non-randomized controlled intervention study conducted among 600 pregnant women with periodontitis. The women will be recruited among all pregnant women at two Danish hospitals in Region Zealand during their nuchal translucency scan and will subsequently be screened for periodontitis. The intervention group includes 300 pregnant women, who will be offered state-of-the-art periodontal treatment during pregnancy. The control group includes additional 300 pregnant women, who will be offered periodontal treatment after giving birth. Outcome measures include periodontal measures, inflammatory, hormonal and glycaemic markers as well as the prevalence of preterm birth risk, low birth weight and risk markers of gestational diabetes mellitus (GDM) and preeclampsia that will be collected from all screened women and further during pregnancy week 20 and pregnancy week 35 for women enrolled in the intervention.ETHICS AND DISSEMINATION: The study's findings will be published in peer reviewed journals and disseminated at national and international conferences and through social media. The PROBE study is designed to provide important new knowledge as to whether periodontal treatment during pregnancy can reduce the prevalence of complications related to pregnancy and birth.CLINICAL TRIALS REGISTRATION: The study was registered on clinicaltrials.gov (NCT06110143).
KW - Adult
KW - Diabetes, Gestational
KW - Female
KW - Humans
KW - Infant, Low Birth Weight
KW - Infant, Newborn
KW - Periodontitis/therapy
KW - Pre-Eclampsia/prevention & control
KW - Pregnancy
KW - Pregnancy Complications/prevention & control
KW - Pregnancy Outcome
KW - Premature Birth/prevention & control
UR - http://www.scopus.com/inward/record.url?scp=85192868726&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0302010
DO - 10.1371/journal.pone.0302010
M3 - Journal article
C2 - 38739615
AN - SCOPUS:85192868726
SN - 1932-6203
VL - 19
SP - e0302010
JO - PLoS One
JF - PLoS One
IS - 5
M1 - e0302010
ER -