The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer. Sub-study of an RCT

Sacha Stormlund*, Negjyp Sopa, Julie Lyng Forman, Anne Zedeler, Jeanette Bogstad, Lisbeth Prætorius, Henriette Svarre Nielsen, Anna Klajnbard, Anne Lis Englund, Søren Ziebe, Nina la Cour Freiesleben, Christina Bergh, Peter Humaidan, Anders Nyboe Andersen, Anja Pinborg, Kristine Løssl

*Corresponding author for this work

Abstract

The effect of late-follicular phase progesterone elevation (LFPE) during ovarian stimulation on reproductive outcomes in ART treatment remains controversial, but recent studies indicate lower pregnancy rates with rising progesterone levels. This study aims to investigate the prevalence of late-follicular phase progesterone elevation (LFPE) and possible impact on ongoing pregnancy rate after fresh or frozen blastocyst transfer in a sub-study setting of a randomised controlled trial. A total of 288 women were included (n=137 and n=151 in the fresh transfer and freeze-all group, respectively). Among these 11(3.8%) had a progesterone level ≥1.5 ng/ml, and 20(6.9%) had a progesterone level ≥1.2 ng/ml on trigger day. Spline regression analysis showed no significant effect of late follicular phase progesterone levels on ongoing pregnancy. In the multivariate regression analysis (n = 312) only age, but not progesterone level on trigger day was significantly associated with ongoing pregnancy. In conclusion, in a clinical setting with moderate gonadotrophin stimulation and well-defined trigger and fresh transfer cancellation criteria, the prevalence of women with LFPE ≥1.5 ng/ml was low and did not indicate the clinical value of routine measurement of progesterone in the late follicular phase.

Original languageEnglish
Article number2265153
JournalHuman fertility (Cambridge, England)
Volume27
Issue number1
Pages (from-to)2265153
ISSN1464-7273
DOIs
Publication statusPublished - Dec 2024

Keywords

  • Female
  • Humans
  • Pregnancy
  • Embryo Transfer
  • Fertilization in Vitro
  • Follicular Phase
  • Ovulation Induction
  • Pregnancy Rate
  • Prevalence
  • Progesterone
  • Serum Progesterone
  • Frozen embryo transfer
  • Ongoing pregnancy rate
  • In vitro fertilisation

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