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The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data

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  4. Use of Oxygen Therapies in Wound Healing: Focus on Topical and Hyperbaric Oxygen Treatment

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  5. Prevalence of skin tears in the extremities among elderly residents at a nursing home in Denmark

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  1. In-vivo gentamicin susceptibility test for prevention of bacterial biofilms in bone tissue and on implants

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  2. UV light assisted antibiotics for eradication of in vitro biofilms

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  3. Biofilm formation - what we can learn from recent developments

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  4. The use of fluorescent staining techniques for microscopic investigation of polymorphonuclear leukocytes and bacteria

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  5. Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis

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  • M Malone
  • T Bjarnsholt
  • A J McBain
  • G A James
  • P Stoodley
  • D Leaper
  • M Tachi
  • G Schultz
  • T Swanson
  • R D Wolcott
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The presence of biofilms in chronic non-healing wounds, has been identified through in vitro model and in vivo animal data. However, human chronic wound studies are under-represented and generally report low sample sizes. For this reason we sought to ascertain the prevalence of biofilms in human chronic wounds by undertaking a systematic review and meta-analysis. Our initial search identified 554 studies from the literature databases (Cochrane Library, Embase, Medline). After removal of duplicates, and those not meeting the requirements of inclusion, nine studies involving 185 chronic wounds met the inclusion criteria. Prevalence of biofilms in chronic wounds was 78.2 % (confidence interval [CI 61.6-89, p<0.002]). The results of our meta-analysis support our clinical assumptions that biofilms are ubiquitous in human chronic non-healing wounds.

Original languageEnglish
JournalJournal of wound care
Volume26
Issue number1
Pages (from-to)20-25
Number of pages6
ISSN0969-0700
DOIs
Publication statusPublished - 2 Jan 2017

    Research areas

  • Journal Article

ID: 49907131