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The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data

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  1. Uncontrolled gelatin degradation in non-healing chronic wounds

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  2. Non-antibiotic antimicrobial interventions and antimicrobial stewardship in wound care

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  3. Wound centres-how do we obtain high quality? The EWMA wound centre endorsement project

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  4. Use of Oxygen Therapies in Wound Healing: Focus on Topical and Hyperbaric Oxygen Treatment

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  5. Prevalence of skin tears in the extremities among elderly residents at a nursing home in Denmark

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  1. Is pseudarthrosis after spinal instrumentation caused by a chronic infection?

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  2. An Equine Wound Model to Study Effects of Bacterial Aggregates on Wound Healing

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  3. Analysis of proximal bone margins in diabetic foot osteomyelitis by conventional culture, DNA sequencing and microscopy

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  4. Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms

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  • M Malone
  • T Bjarnsholt
  • A J McBain
  • G A James
  • P Stoodley
  • D Leaper
  • M Tachi
  • G Schultz
  • T Swanson
  • R D Wolcott
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The presence of biofilms in chronic non-healing wounds, has been identified through in vitro model and in vivo animal data. However, human chronic wound studies are under-represented and generally report low sample sizes. For this reason we sought to ascertain the prevalence of biofilms in human chronic wounds by undertaking a systematic review and meta-analysis. Our initial search identified 554 studies from the literature databases (Cochrane Library, Embase, Medline). After removal of duplicates, and those not meeting the requirements of inclusion, nine studies involving 185 chronic wounds met the inclusion criteria. Prevalence of biofilms in chronic wounds was 78.2 % (confidence interval [CI 61.6-89, p<0.002]). The results of our meta-analysis support our clinical assumptions that biofilms are ubiquitous in human chronic non-healing wounds.

Original languageEnglish
JournalJournal of wound care
Volume26
Issue number1
Pages (from-to)20-25
Number of pages6
ISSN0969-0700
DOIs
Publication statusPublished - 2 Jan 2017

    Research areas

  • Journal Article

ID: 49907131