Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The prevalence and determinants of anti-DFS70 autoantibodies in an international inception cohort of systemic lupus erythematosus patients

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Breast cancer in systemic lupus

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. A fluorescence sedimentation assay for dsDNA antibodies

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Breast cancer in systemic lupus

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men

    Research output: Contribution to journalJournal articleResearchpeer-review

  • M Y Choi
  • A E Clarke
  • Y St Pierre
  • J G Hanly
  • M B Urowitz
  • J Romero-Diaz
  • C Gordon
  • S-C Bae
  • S Bernatsky
  • D J Wallace
  • J T Merrill
  • D A Isenberg
  • A Rahman
  • E M Ginzler
  • M Petri
  • I N Bruce
  • M A Dooley
  • P Fortin
  • D D Gladman
  • J Sanchez-Guerrero
  • K Steinsson
  • R Ramsey-Goldman
  • M A Khamashta
  • C Aranow
  • G S Alarcón
  • S Manzi
  • O Nived
  • A A Zoma
  • R F van Vollenhoven
  • M Ramos-Casals
  • G Ruiz-Irastorza
  • S S Lim
  • K C Kalunian
  • M Inanc
  • D L Kamen
  • C A Peschken
  • S Jacobsen
  • A Askanase
  • J Buyon
  • M Mahler
  • M J Fritzler
View graph of relations

Autoantibodies to dense fine speckles 70 (DFS70) are purported to rule out the diagnosis of SLE when they occur in the absence of other SLE-related autoantibodies. This study is the first to report the prevalence of anti-DFS70 in an early, multinational inception SLE cohort and examine demographic, clinical, and autoantibody associations. Patients were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis. The association between anti-DFS70 and multiple parameters in 1137 patients was assessed using univariate and multivariate logistic regression. The frequency of anti-DFS70 was 7.1% (95% CI: 5.7-8.8%), while only 1.1% (95% CI: 0.6-1.9%) were monospecific for anti-DFS70. In multivariate analysis, patients with musculoskeletal activity (Odds Ratio (OR) 1.24 [95% CI: 1.10, 1.41]) or with anti-β2 glycoprotein 1 (OR 2.17 [95% CI: 1.22, 3.87]) were more likely and patients with anti-dsDNA (OR 0.53 [95% CI: 0.31, 0.92]) or anti-SSB/La (OR 0.25 [95% CI: 0.08, 0.81]) were less likely to have anti-DFS70. In this study, the prevalence of anti-DFS70 was higher than the range previously published for adult SLE (7.1 versus 0-2.8%) and was associated with musculoskeletal activity and anti-β2 glycoprotein 1 autoantibodies. However, 'monospecific' anti-DFS70 autoantibodies were rare (1.1%) and therefore may be helpful to discriminate between ANA-positive healthy individuals and SLE.

Original languageEnglish
JournalLupus
Volume26
Issue number10
Pages (from-to)1051-1059
Number of pages9
ISSN0961-2033
DOIs
Publication statusPublished - Sep 2017

    Research areas

  • Journal Article

ID: 52378383