The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study

Harvey O Coxson; Asger Dirksen; Lisa D Edwards; Julie C Yates; Alvar Agusti; Per Bakke; Peter Ma Calverley; Bartolome Celli; Courtney Crim; Annelyse Duvoix; Paola Nasute Fauerbach; David A Lomas; William Macnee; Ruth J Mayer; Bruce E Miller; Nestor L Müller; Stephen I Rennard; Edwin K Silverman; Ruth Tal-Singer; Emiel Fm Wouters; Jørgen Vestbo; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators

doi:10.1016/S2213-2600(13)70006-7

The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study

Harvey O Coxson, Asger Dirksen, Lisa D Edwards, Julie C Yates, Alvar Agusti, Per Bakke, Peter Ma Calverley, Bartolome Celli, Courtney Crim, Annelyse Duvoix, Paola Nasute Fauerbach, David A Lomas, William Macnee, Ruth J Mayer, Bruce E Miller, Nestor L Müller, Stephen I Rennard, Edwin K Silverman, Ruth Tal-Singer, Emiel Fm WoutersJørgen Vestbo, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators

250 Citations (Scopus)

Abstract

Emphysema is a key contributor to airflow limitation in chronic obstructive pulmonary disease (COPD) and can be quantified using CT scanning. We investigated the change in CT lung density in a longitudinal, international cohort of patients with COPD. We also explored the potential relation between emphysema and patient characteristics, and investigated if certain circulating biomarkers were associated with decline in CT lung density.

Original language	English
Journal	The Lancet Respiratory Medicine
Volume	1
Issue number	2
Pages (from-to)	129-36
Number of pages	8
ISSN	2213-2600
DOIs	https://doi.org/10.1016/S2213-2600(13)70006-7
Publication status	Published - Apr 2013

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Coxson, H. O., Dirksen, A., Edwards, L. D., Yates, J. C., Agusti, A., Bakke, P., Calverley, P. M., Celli, B., Crim, C., Duvoix, A., Fauerbach, P. N., Lomas, D. A., Macnee, W., Mayer, R. J., Miller, B. E., Müller, N. L., Rennard, S. I., Silverman, E. K., Tal-Singer, R., ... Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators (2013). The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study. The Lancet Respiratory Medicine, 1(2), 129-36. https://doi.org/10.1016/S2213-2600(13)70006-7

The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study. / Coxson, Harvey O; Dirksen, Asger; Edwards, Lisa D et al.
In: The Lancet Respiratory Medicine, Vol. 1, No. 2, 04.2013, p. 129-36.

Research output: Contribution to journal › Journal article › Research › peer-review

Coxson, HO, Dirksen, A, Edwards, LD, Yates, JC, Agusti, A, Bakke, P, Calverley, PM, Celli, B, Crim, C, Duvoix, A, Fauerbach, PN, Lomas, DA, Macnee, W, Mayer, RJ, Miller, BE, Müller, NL, Rennard, SI, Silverman, EK, Tal-Singer, R, Wouters, EF, Vestbo, J & Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators 2013, 'The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study', The Lancet Respiratory Medicine, vol. 1, no. 2, pp. 129-36. https://doi.org/10.1016/S2213-2600(13)70006-7

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abstract = "Emphysema is a key contributor to airflow limitation in chronic obstructive pulmonary disease (COPD) and can be quantified using CT scanning. We investigated the change in CT lung density in a longitudinal, international cohort of patients with COPD. We also explored the potential relation between emphysema and patient characteristics, and investigated if certain circulating biomarkers were associated with decline in CT lung density.",

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AU - Bakke, Per

AU - Calverley, Peter Ma

AU - Celli, Bartolome

AU - Crim, Courtney

AU - Duvoix, Annelyse

AU - Fauerbach, Paola Nasute

AU - Lomas, David A

AU - Macnee, William

AU - Mayer, Ruth J

AU - Miller, Bruce E

AU - Müller, Nestor L

AU - Rennard, Stephen I

AU - Silverman, Edwin K

AU - Tal-Singer, Ruth

AU - Wouters, Emiel Fm

AU - Vestbo, Jørgen

AU - Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators

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AB - Emphysema is a key contributor to airflow limitation in chronic obstructive pulmonary disease (COPD) and can be quantified using CT scanning. We investigated the change in CT lung density in a longitudinal, international cohort of patients with COPD. We also explored the potential relation between emphysema and patient characteristics, and investigated if certain circulating biomarkers were associated with decline in CT lung density.

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The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study

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