Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The POSEIDON Criteria and Its Measure of Success Through the Eyes of Clinicians and Embryologists

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Editorial: Novel Biomarkers for Type 2 Diabetes

    Research output: Contribution to journalEditorialResearchpeer-review

  2. Editorial: The Role of Genetic and Lifestyle Factors in Metabolic Diseases

    Research output: Contribution to journalEditorialResearchpeer-review

  3. Liraglutide-Induced Weight Loss May be Affected by Autonomic Regulation in Type 1 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. In-utero Exposure to Maternal Stressful Life Events and Risk of Cryptorchidism: The Raine Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Gene Expression in Granulosa Cells From Small Antral Follicles From Women With or Without Polycystic Ovaries

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Quantitative Differences in TGF-β Family Members Measured in Small Antral Follicle Fluids From Women With or Without PCO

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Xeno-Free Propagation of Spermatogonial Stem Cells from Infant Boys

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Sandro C Esteves
  • Carlo Alviggi
  • Peter Humaidan
  • Robert Fischer
  • Claus Y Andersen
  • Alessandro Conforti
  • Klaus Bühler
  • Sesh K Sunkara
  • Nikolaos P Polyzos
  • Daniela Galliano
  • Michael Grynberg
  • Hakan Yarali
  • Irem Y Özbek
  • Matheus Roque
  • Lan N Vuong
  • Manish Banker
  • Laura Rienzi
  • Alberto Vaiarelli
  • Danilo Cimadomo
  • Filippo M Ubaldi
View graph of relations

This article represents a viewpoint on the POSEIDON criteria by a group of clinicians and embryologists. Its primary objective is to contextualize the Poseidon criteria and their metric of success for the relevant Frontiers Research Topic "POSEIDON's Stratification of Low Prognosis Patients in ART: The WHY, the WHAT, and the HOW". "Low prognosis" relates with reduced oocyte number, which can be associated with low or sometimes a normal ovarian reserve and is aggravated by advanced female age. These aspects will ultimately affect the number of embryos generated and consequently, the cumulative live birth rate. The novel system relies on female age, ovarian reserve markers, ovarian sensitivity to exogenous gonadotropin, and the number of oocytes retrieved, which will both identify the patients with low prognosis and stratify such patients into one of four groups of women with "expected" or "unexpected" impaired ovarian response to exogenous gonadotropin stimulation. Furthermore, the POSEIDON group introduced a new measure of clinical success in ART, namely, the ability to retrieve the number of oocytes needed to obtain at least one euploid blastocyst for transfer in each patient. Using the POSEIDON criteria, the clinician can firstly identify and classify patients who have low prognosis in ART, and secondly, aim at designing an individualized treatment plan to maximize the chances of achieving the POSEIDON measure of success in each of the four low prognosis groups. The novel POSEIDON classification system is anticipated to improve counseling and management of low prognosis patients undergoing ART, with an expected positive effect on reproductive success and a reduction in the time to live birth.

Original languageEnglish
JournalFrontiers in Endocrinology
Volume10
Pages (from-to)814
ISSN1664-2392
DOIs
Publication statusPublished - 2019

ID: 59044337