Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The plasma pharmacokinetics of fosfomycin and metronidazole after intraperitoneal administration in patients undergoing appendectomy for uncomplicated appendicitis

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Targeting the aldosterone pathway in cardiovascular disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Protection against β adrenoceptor agonist reduction of plasma potassium in severe but not in moderate hypokalemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Strategy for clinical evaluation and screening of sudden cardiac death relatives

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Sudden cardiac death--the challenge to cardiology

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. New strategies in insulin treatment: analogues and noninvasive routes of administration

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Long-term mortality in the Intermediate care after emergency abdominal surgery (InCare) trial - a post-hoc follow-up study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prevalence of Infective Endocarditis in Streptococcal Bloodstream Infections is Dependent on Streptococcal Species

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. More than one-third of Cochrane reviews had gift authors, whereas ghost authorship was rare

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Group authorships in Cochrane had low compliance with Cochrane recommendations

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

We aimed to investigate the pharmacokinetics of fosfomycin and metronidazole after intraperitoneal administration of the combination of fosfomycin and metronidazole in patients undergoing laparoscopic appendectomy for uncomplicated appendicitis. We included eight otherwise healthy men undergoing laparoscopic appendectomy. The trial treatment was administered at the end of the surgical procedure and left in the abdominal cavity. Trial drugs consisted of 4 g fosfomycin and 1 g metronidazole in a total volume of 500.2 mL. Blood samples were collected prior to and ½, 1, 2, 4, 8, 12 and 24 h after administration. High-performance liquid chromatography-mass spectrometry was used for the measurement of plasma concentrations, and pharmacokinetic calculations were undertaken. Antimicrobial susceptibility testing was undertaken on isolates from intraoperatively collected specimens. The median maximal concentration for fosfomycin in plasma was 104.4 mg/L, median time point for the maximal concentration was 1.5 h, median half-life 3.0 h, and median area under the curve 608 mg*h/L. The median maximal concentration for metronidazole in plasma was 13.6 mg/L, median time point for the maximal concentration was 2.0 h, median half-life 7.3 h, and median area under the curve was 164 mg*h/L. All aerobic bacteria were susceptible to fosfomycin, and all anaerobes were susceptible to metronidazole. Plasma concentrations of fosfomycin and metronidazole were in line with concentrations reported from pharmacokinetic studies after intravenous administration and were within therapeutic ranges.

Original languageEnglish
JournalFundamental & clinical pharmacology
Volume34
Issue number4
Pages (from-to)504-512
Number of pages9
ISSN0767-3981
DOIs
Publication statusPublished - Aug 2020

ID: 60988118