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The OMERACT-OARSI Core Domain Set for Measurement in Clinical Trials of Hip and/or Knee Osteoarthritis

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Adaptive Trial Designs in Rheumatology: Report from the OMERACT Special Interest Group

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. OMERACT Development of a Core Domain Set of Outcomes for Shared Decision-making Interventions

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Core Outcome Sets Specifically for Longterm Observational Studies: OMERACT Special Interest Group Update in Rheumatoid Arthritis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Adaptive Trial Designs in Rheumatology: Report from the OMERACT Special Interest Group

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. OMERACT Development of a Core Domain Set of Outcomes for Shared Decision-making Interventions

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Core Outcome Sets Specifically for Longterm Observational Studies: OMERACT Special Interest Group Update in Rheumatoid Arthritis

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Toby O Smith
  • Gillian A Hawker
  • David J Hunter
  • Lyn M March
  • Maarten Boers
  • Beverley J Shea
  • Robin Christensen
  • Francis Guillemin
  • Caroline B Terwee
  • Paula R Williamson
  • Susanna Dodd
  • Ewa M Roos
  • Richard F Loeser
  • Thomas J Schnitzer
  • Margreet Kloppenburg
  • Tuhina Neogi
  • Christoph H Ladel
  • Gurdyal Kalsi
  • Ulrike Kaiser
  • Thomas W Buttel
  • Anne E Ashford
  • Ali Mobasheri
  • Nigel K Arden
  • Alan Tennant
  • Marc C Hochberg
  • Maarten de Wit
  • Peter Tugwell
  • Philip G Conaghan
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OBJECTIVE: To update the 1997 OMERACT-OARSI (Outcome Measures in Rheumatology-Osteoarthritis Research Society International) core domain set for clinical trials in hip and/or knee osteoarthritis (OA).

METHODS: An initial review of the COMET database of core outcome sets (COS) was undertaken to identify all domains reported in previous COS including individuals with hip and/or knee OA. These were presented during 5 patient and health professionals/researcher meetings in 3 continents (Europe, Australasia, North America). A 3-round international Delphi survey was then undertaken among patients, healthcare professionals, researchers, and industry representatives to gain consensus on key domains to be included in a core domain set for hip and/or knee OA. Findings were presented and discussed in small groups at OMERACT 2018, where consensus was obtained in the final plenary.

RESULTS: Four previous COS were identified. Using these, and the patient and health professionals/researcher meetings, 50 potential domains formed the Delphi survey. There were 426 individuals from 25 different countries who contributed to the Delphi exercise. OMERACT 2018 delegates (n = 129) voted on candidate domains. Six domains gained agreement as mandatory to be measured and reported in all hip and/or knee OA clinical trials: pain, physical function, quality of life, and patient's global assessment of the target joint, in addition to the mandated core domain of adverse events including mortality. Joint structure was agreed as mandatory in specific circumstances, i.e., depending on the intervention.

CONCLUSION: The updated core domain set for hip and/or knee OA has been agreed upon. Work will commence to determine which outcome measurement instrument should be recommended to cover each core domain.

Original languageEnglish
JournalJournal of Rheumatology
Volume46
Issue number8
Pages (from-to)981-989
Number of pages9
ISSN0315-162X
DOIs
Publication statusPublished - Aug 2019

ID: 57855268