The OMERACT MRI in Enthesitis Initiative: Definitions of Key Pathologies, Suggested MRI Sequences, and a Novel Heel Enthesitis Scoring System

Ashish J Mathew; Simon Krabbe; Iris Eshed; Frédérique Gandjbakhch; Paul Bird; Susanne Juhl Pedersen; Maria S Stoenoiu; Violaine Foltz; Daniel Erik Glinatsi; Robert G Lambert; Kay Geert A Hermann; Walter P Maksymowych; Ida K Haugen; Jacob L Jaremko; René Panduro Poggenborg; Joel Paschke; Jean-Denis Laredo; Philippe Carron; Philip G Conaghan; Mikkel Østergaard

doi:10.3899/jrheum.181093

The OMERACT MRI in Enthesitis Initiative: Definitions of Key Pathologies, Suggested MRI Sequences, and a Novel Heel Enthesitis Scoring System

Ashish J Mathew
, Simon Krabbe
, Iris Eshed
, Frédérique Gandjbakhch
, Paul Bird
, Susanne Juhl Pedersen
, Maria S Stoenoiu
, Violaine Foltz
, Daniel Erik Glinatsi
, Robert G Lambert
, Kay Geert A Hermann
, Walter P Maksymowych
, Ida K Haugen
, Jacob L Jaremko
, René Panduro Poggenborg
, Joel Paschke
, Jean-Denis Laredo
, Philippe Carron
, Philip G Conaghan
, Mikkel Østergaard

Department for Rheumatology and Spine Diseases

55 Citations (Scopus)

Abstract

OBJECTIVE: To develop and validate an enthesitis magnetic resonance imaging (MRI) scoring system for spondyloarthritis/psoriatic arthritis, using the heel as model.

METHODS: Consensus definitions of key pathologies and 3 heel enthesitis multireader scoring exercises were done, separated by discussion, training, and calibration.

RESULTS: Definitions for bone and soft tissue pathologies were agreed. In the final exercise, median pairwise single-measures intraclass correlation coefficients (ICC; patient-level) for entheseal inflammation status/change scores were 0.83/0.82 for all readers. For radiologists and selected rheumatologists, ICC were 0.91/0.84 and quadratic-weighted κ (lesion-level) 0.57-0.91/0.45-0.81.

CONCLUSION: The proposed definitions and Heel Enthesitis Scoring System (HEMRIS) are reliable among trained readers and promising for clinical trials.

Original language	English
Journal	Journal of Rheumatology
Volume	46
Issue number	9
Pages (from-to)	1232-1238
Number of pages	7
ISSN	0315-162X
DOIs	https://doi.org/10.3899/jrheum.181093
Publication status	Published - Sept 2019

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Mathew, A. J., Krabbe, S., Eshed, I., Gandjbakhch, F., Bird, P., Pedersen, S. J., Stoenoiu, M. S., Foltz, V., Glinatsi, D. E., Lambert, R. G., Hermann, K. G. A., Maksymowych, W. P., Haugen, I. K., Jaremko, J. L., Poggenborg, R. P., Paschke, J., Laredo, J.-D., Carron, P., Conaghan, P. G., & Østergaard, M. (2019). The OMERACT MRI in Enthesitis Initiative: Definitions of Key Pathologies, Suggested MRI Sequences, and a Novel Heel Enthesitis Scoring System. Journal of Rheumatology, 46(9), 1232-1238. https://doi.org/10.3899/jrheum.181093

Mathew, AJ, Krabbe, S, Eshed, I, Gandjbakhch, F, Bird, P, Pedersen, SJ, Stoenoiu, MS, Foltz, V, Glinatsi, DE, Lambert, RG, Hermann, KGA, Maksymowych, WP, Haugen, IK, Jaremko, JL, Poggenborg, RP, Paschke, J, Laredo, J-D, Carron, P, Conaghan, PG & Østergaard, M 2019, 'The OMERACT MRI in Enthesitis Initiative: Definitions of Key Pathologies, Suggested MRI Sequences, and a Novel Heel Enthesitis Scoring System', Journal of Rheumatology, vol. 46, no. 9, pp. 1232-1238. https://doi.org/10.3899/jrheum.181093

@article{b7a6c0a42ab84a0e9b3c0555c16901b7,

title = "The OMERACT MRI in Enthesitis Initiative: Definitions of Key Pathologies, Suggested MRI Sequences, and a Novel Heel Enthesitis Scoring System",

abstract = "OBJECTIVE: To develop and validate an enthesitis magnetic resonance imaging (MRI) scoring system for spondyloarthritis/psoriatic arthritis, using the heel as model.METHODS: Consensus definitions of key pathologies and 3 heel enthesitis multireader scoring exercises were done, separated by discussion, training, and calibration.RESULTS: Definitions for bone and soft tissue pathologies were agreed. In the final exercise, median pairwise single-measures intraclass correlation coefficients (ICC; patient-level) for entheseal inflammation status/change scores were 0.83/0.82 for all readers. For radiologists and selected rheumatologists, ICC were 0.91/0.84 and quadratic-weighted κ (lesion-level) 0.57-0.91/0.45-0.81.CONCLUSION: The proposed definitions and Heel Enthesitis Scoring System (HEMRIS) are reliable among trained readers and promising for clinical trials.",

author = "Mathew, \{Ashish J\} and Simon Krabbe and Iris Eshed and Fr{\'e}d{\'e}rique Gandjbakhch and Paul Bird and Pedersen, \{Susanne Juhl\} and Stoenoiu, \{Maria S\} and Violaine Foltz and Glinatsi, \{Daniel Erik\} and Lambert, \{Robert G\} and Hermann, \{Kay Geert A\} and Maksymowych, \{Walter P\} and Haugen, \{Ida K\} and Jaremko, \{Jacob L\} and Poggenborg, \{Ren{\'e} Panduro\} and Joel Paschke and Jean-Denis Laredo and Philippe Carron and Conaghan, \{Philip G\} and Mikkel {\O}stergaard",

note = "COPECARE",

year = "2019",

month = sep,

doi = "10.3899/jrheum.181093",

language = "English",

volume = "46",

pages = "1232--1238",

journal = "Journal of Rheumatology",

issn = "0315-162X",

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TY - JOUR

T1 - The OMERACT MRI in Enthesitis Initiative

T2 - Definitions of Key Pathologies, Suggested MRI Sequences, and a Novel Heel Enthesitis Scoring System

AU - Mathew, Ashish J

AU - Krabbe, Simon

AU - Eshed, Iris

AU - Gandjbakhch, Frédérique

AU - Bird, Paul

AU - Pedersen, Susanne Juhl

AU - Stoenoiu, Maria S

AU - Foltz, Violaine

AU - Glinatsi, Daniel Erik

AU - Lambert, Robert G

AU - Hermann, Kay Geert A

AU - Maksymowych, Walter P

AU - Haugen, Ida K

AU - Jaremko, Jacob L

AU - Poggenborg, René Panduro

AU - Paschke, Joel

AU - Laredo, Jean-Denis

AU - Carron, Philippe

AU - Conaghan, Philip G

AU - Østergaard, Mikkel

N1 - COPECARE

PY - 2019/9

Y1 - 2019/9

N2 - OBJECTIVE: To develop and validate an enthesitis magnetic resonance imaging (MRI) scoring system for spondyloarthritis/psoriatic arthritis, using the heel as model.METHODS: Consensus definitions of key pathologies and 3 heel enthesitis multireader scoring exercises were done, separated by discussion, training, and calibration.RESULTS: Definitions for bone and soft tissue pathologies were agreed. In the final exercise, median pairwise single-measures intraclass correlation coefficients (ICC; patient-level) for entheseal inflammation status/change scores were 0.83/0.82 for all readers. For radiologists and selected rheumatologists, ICC were 0.91/0.84 and quadratic-weighted κ (lesion-level) 0.57-0.91/0.45-0.81.CONCLUSION: The proposed definitions and Heel Enthesitis Scoring System (HEMRIS) are reliable among trained readers and promising for clinical trials.

AB - OBJECTIVE: To develop and validate an enthesitis magnetic resonance imaging (MRI) scoring system for spondyloarthritis/psoriatic arthritis, using the heel as model.METHODS: Consensus definitions of key pathologies and 3 heel enthesitis multireader scoring exercises were done, separated by discussion, training, and calibration.RESULTS: Definitions for bone and soft tissue pathologies were agreed. In the final exercise, median pairwise single-measures intraclass correlation coefficients (ICC; patient-level) for entheseal inflammation status/change scores were 0.83/0.82 for all readers. For radiologists and selected rheumatologists, ICC were 0.91/0.84 and quadratic-weighted κ (lesion-level) 0.57-0.91/0.45-0.81.CONCLUSION: The proposed definitions and Heel Enthesitis Scoring System (HEMRIS) are reliable among trained readers and promising for clinical trials.

U2 - 10.3899/jrheum.181093

DO - 10.3899/jrheum.181093

M3 - Journal article

C2 - 30709961

SN - 0315-162X

VL - 46

SP - 1232

EP - 1238

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 9

ER -

The OMERACT MRI in Enthesitis Initiative: Definitions of Key Pathologies, Suggested MRI Sequences, and a Novel Heel Enthesitis Scoring System

Abstract

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