Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The neurophenomenology of early psychosis: An integrative empirical study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Thought insertion and disturbed for-me-ness (minimal selfhood) in schizophrenia

    Research output: Contribution to journalReviewResearchpeer-review

  2. Mysticism and schizophrenia: A phenomenological exploration of the structure of consciousness in the schizophrenia spectrum disorders

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The "minimal self" in psychopathology: re-examining the self-disorders in the schizophrenia spectrum

    Research output: Contribution to journalJournal articleResearch

  4. Is conscious perception gradual or dichotomous? A comparison of report methodologies during a visual task.

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. 'The schizophrenic basic mood (self-disorder)', by Hans W Gruhle (1929)

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Introduction - Section 15: Part III Taxonomy, Integration, and Multiple Levels of Explanation

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  3. Introduction - Section 4: Part II Phenomenology, Biological Psychology, and the Mind–body Problem

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  4. Introduction - Section 5: Part II Phenomenology, Biological Psychology, and the Mind–body Problem

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  5. Introduction - Section 8: Part III Taxonomy, Integration, and Multiple Levels of Explanation

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  • B Nelson
  • S Lavoie
  • Ł Gawęda
  • E Li
  • L A Sass
  • D Koren
  • P D McGorry
  • B N Jack
  • J Parnas
  • A Polari
  • K Allott
  • J A Hartmann
  • T J Whitford
View graph of relations

BACKGROUND: The integration of various domains or levels of analysis (clinical, neurobiological, genetic, etc.) has been a challenge in schizophrenia research. A promising approach is to use the core phenomenological features of the disorder as an organising principle for other levels of analysis. Minimal self-disturbance (fragility in implicit first-person perspective, presence and agency) is emerging as a strong candidate to play this role. This approach was adopted in a previously described theoretical neurophenomenological model that proposed that source monitoring deficits and aberrant salience may be neurocognitive/neurobiological processes that correlate with minimal self-disturbance on the phenomenological level, together playing an aetiological role in the onset of schizophrenia spectrum disorders. The current paper presents full cross-sectional data from the first empirical test of this model.

METHODS: Fifty ultra-high risk for psychosis patients, 39 first episode psychosis patients and 34 healthy controls were assessed with a variety of clinical measures, including the Examination of Anomalous Self-Experience (EASE), and neurocognitive and neurophysiological (EEG) measures of source monitoring deficits and aberrant salience.

RESULTS: Linear regression indicated that source monitoring (composite score across neurocognitive and neurophysiological measures), with study group as an interaction term, explained 39.8% of the variance in EASE scores (R2 = 0.41, F(3,85) = 14.78, p < 0.001), whereas aberrant salience (composite score) explained only 6% of the variance in EASE scores (R2 = 0.06, F(3,85) = 1.44, p = 0.93). Aberrant salience measures were more strongly related to general psychopathology measures, particularly to positive psychotic symptoms, than to EASE scores.

DISCUSSION: A neurophenomenological model of minimal self-disturbance in schizophrenia spectrum disorders may need to be expanded from source monitoring deficits to encompass other relevant constructs such as temporal processing, intermodal/multisensory integration, and hierarchical predictive processing. The cross-sectional data reported here will be expanded with longitudinal analysis in subsequent reports. These data and other related recent research show an emerging picture of neuro-features of core phenomenological aspects of schizophrenia spectrum disorders beyond surface-level psychotic symptoms.

Original languageEnglish
JournalConsciousness and Cognition
Volume77
Pages (from-to)102845
ISSN1053-8100
DOIs
Publication statusPublished - Jan 2020

ID: 58972729