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The myelin content of the human precentral hand knob reflects interindividual differences in manual motor control at the physiological and behavioral level

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@article{0a510da2a6624086a3ed8b0eb30f7708,
title = "The myelin content of the human precentral hand knob reflects interindividual differences in manual motor control at the physiological and behavioral level",
abstract = "The primary motor cortex hand area (M1HAND) and adjacent dorsal premotor cortex (PMd) form the so-called motor hand knob in the precentral gyrus. M1HAND and PMd are critical for dexterous hand use and are densely interconnected via corticocortical axons, lacking a sharp demarcating border. In 24 young right-handed volunteers, we performed multimodal mapping to delineate the relationship between structure and function in the right motor hand knob. Quantitative structural magnetic resonance imaging (MRI) at 3 tesla yielded regional R1 maps as a proxy of cortical myelin content. Participants also underwent functional MRI (fMRI). We mapped task-related activation and temporal precision, while they performed a visuomotor synchronization task requiring visually cued abduction movements with the left index or little finger. We also performed sulcus-aligned transcranial magnetic stimulation of the motor hand knob to localize the optimal site (hotspot) for evoking a motor evoked potential (MEP) in two intrinsic hand muscles. Individual motor hotspot locations varied along the rostrocaudal axis. The more rostral the motor hotspot location in the precentral crown, the longer were corticomotor MEP latencies. {"}Hotspot rostrality{"}was associated with the regional myelin content in the precentral hand knob. Cortical myelin content also correlated positively with task-related activation of the precentral crown and temporal precision during the visuomotor synchronization task. Together, our results suggest a link among cortical myelination, the spatial cortical representation, and temporal precision of finger movements. We hypothesize that the myelination of cortical axons facilitates neuronal integration in PMd and M1HAND and, hereby, promotes the precise timing of movements.",
keywords = "Functional cortical mapping, Magnetic resonance imaging, Motor skill, Premotor cortex, Primary motor cortex",
author = "Raffaele Dubbioso and Madsen, {Kristoffer Hougaard} and Axel Thielscher and Siebner, {Hartwig Roman}",
note = "Copyright {\textcopyright} 2021 Dubbioso et al.",
year = "2021",
month = apr,
day = "7",
doi = "10.1523/JNEUROSCI.0390-20.2021",
language = "English",
volume = "41",
pages = "3163--3179",
journal = "Neuroscience Journal",
issn = "2314-4262",
publisher = "Hindawi Publishing Corporation",
number = "14",

}

RIS

TY - JOUR

T1 - The myelin content of the human precentral hand knob reflects interindividual differences in manual motor control at the physiological and behavioral level

AU - Dubbioso, Raffaele

AU - Madsen, Kristoffer Hougaard

AU - Thielscher, Axel

AU - Siebner, Hartwig Roman

N1 - Copyright © 2021 Dubbioso et al.

PY - 2021/4/7

Y1 - 2021/4/7

N2 - The primary motor cortex hand area (M1HAND) and adjacent dorsal premotor cortex (PMd) form the so-called motor hand knob in the precentral gyrus. M1HAND and PMd are critical for dexterous hand use and are densely interconnected via corticocortical axons, lacking a sharp demarcating border. In 24 young right-handed volunteers, we performed multimodal mapping to delineate the relationship between structure and function in the right motor hand knob. Quantitative structural magnetic resonance imaging (MRI) at 3 tesla yielded regional R1 maps as a proxy of cortical myelin content. Participants also underwent functional MRI (fMRI). We mapped task-related activation and temporal precision, while they performed a visuomotor synchronization task requiring visually cued abduction movements with the left index or little finger. We also performed sulcus-aligned transcranial magnetic stimulation of the motor hand knob to localize the optimal site (hotspot) for evoking a motor evoked potential (MEP) in two intrinsic hand muscles. Individual motor hotspot locations varied along the rostrocaudal axis. The more rostral the motor hotspot location in the precentral crown, the longer were corticomotor MEP latencies. "Hotspot rostrality"was associated with the regional myelin content in the precentral hand knob. Cortical myelin content also correlated positively with task-related activation of the precentral crown and temporal precision during the visuomotor synchronization task. Together, our results suggest a link among cortical myelination, the spatial cortical representation, and temporal precision of finger movements. We hypothesize that the myelination of cortical axons facilitates neuronal integration in PMd and M1HAND and, hereby, promotes the precise timing of movements.

AB - The primary motor cortex hand area (M1HAND) and adjacent dorsal premotor cortex (PMd) form the so-called motor hand knob in the precentral gyrus. M1HAND and PMd are critical for dexterous hand use and are densely interconnected via corticocortical axons, lacking a sharp demarcating border. In 24 young right-handed volunteers, we performed multimodal mapping to delineate the relationship between structure and function in the right motor hand knob. Quantitative structural magnetic resonance imaging (MRI) at 3 tesla yielded regional R1 maps as a proxy of cortical myelin content. Participants also underwent functional MRI (fMRI). We mapped task-related activation and temporal precision, while they performed a visuomotor synchronization task requiring visually cued abduction movements with the left index or little finger. We also performed sulcus-aligned transcranial magnetic stimulation of the motor hand knob to localize the optimal site (hotspot) for evoking a motor evoked potential (MEP) in two intrinsic hand muscles. Individual motor hotspot locations varied along the rostrocaudal axis. The more rostral the motor hotspot location in the precentral crown, the longer were corticomotor MEP latencies. "Hotspot rostrality"was associated with the regional myelin content in the precentral hand knob. Cortical myelin content also correlated positively with task-related activation of the precentral crown and temporal precision during the visuomotor synchronization task. Together, our results suggest a link among cortical myelination, the spatial cortical representation, and temporal precision of finger movements. We hypothesize that the myelination of cortical axons facilitates neuronal integration in PMd and M1HAND and, hereby, promotes the precise timing of movements.

KW - Functional cortical mapping

KW - Magnetic resonance imaging

KW - Motor skill

KW - Premotor cortex

KW - Primary motor cortex

UR - http://www.scopus.com/inward/record.url?scp=85104047659&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.0390-20.2021

DO - 10.1523/JNEUROSCI.0390-20.2021

M3 - Journal article

C2 - 33653698

VL - 41

SP - 3163

EP - 3179

JO - Neuroscience Journal

JF - Neuroscience Journal

SN - 2314-4262

IS - 14

ER -

ID: 64081908