The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load

Malene Hornbak; Karina Banasik; Johanne Marie Justesen; Nikolaj Thure Krarup; Camilla Helene Sandholt; Åsa Andersson; Annelli Sandbæk; Torsten Lauritzen; Charlotta Pisinger; Daniel Rinse Witte; Thorkild Ingvor A Sørensen; Oluf Borbye Pedersen; Torben Hansen

doi:10.1186/1471-2350-12-4

The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load

Malene Hornbak, Karina Banasik, Johanne Marie Justesen, Nikolaj Thure Krarup, Camilla Helene Sandholt, Åsa Andersson, Annelli Sandbæk, Torsten Lauritzen, Charlotta Pisinger, Daniel Rinse Witte, Thorkild Ingvor A Sørensen, Oluf Borbye Pedersen, Torben Hansen

10 Citations (Scopus)

Abstract

A genome-wide association study (GWAS) using metabolite concentrations as proxies for enzymatic activity, suggested that two variants: rs2014355 in the gene encoding short-chain acyl-coenzyme A dehydrogenase (ACADS) and rs11161510 in the gene encoding medium-chain acyl-coenzyme A dehydrogenase (ACADM) impair fatty acid β-oxidation. Chronic exposure to fatty acids due to an impaired β-oxidation may down-regulate the glucose-stimulated insulin release and result in an increased risk of type 2 diabetes (T2D). We aimed to investigate whether the two variants associate with altered insulin release following an oral glucose load or with T2D.

Original language	English
Journal	B M C Medical Genetics
Volume	12
Pages (from-to)	4
ISSN	1471-2350
DOIs	https://doi.org/10.1186/1471-2350-12-4
Publication status	Published - 2011

Keywords

Adult
Alleles
Blood Glucose
Butyryl-CoA Dehydrogenase
Case-Control Studies
Clinical Trials as Topic
Cohort Studies
Diabetes Mellitus, Type 2
Female
Glucose Tolerance Test
Humans
Insulin
Male
Middle Aged
Prevalence

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10.1186/1471-2350-12-4

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Hornbak, M., Banasik, K., Justesen, J. M., Krarup, N. T., Sandholt, C. H., Andersson, Å., Sandbæk, A., Lauritzen, T., Pisinger, C., Witte, D. R., Sørensen, T. I. A., Pedersen, O. B., & Hansen, T. (2011). The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load. B M C Medical Genetics, 12, 4. https://doi.org/10.1186/1471-2350-12-4

Hornbak, M, Banasik, K, Justesen, JM, Krarup, NT, Sandholt, CH, Andersson, Å, Sandbæk, A, Lauritzen, T, Pisinger, C, Witte, DR, Sørensen, TIA, Pedersen, OB & Hansen, T 2011, 'The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load', B M C Medical Genetics, vol. 12, pp. 4. https://doi.org/10.1186/1471-2350-12-4

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title = "The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load",

abstract = "A genome-wide association study (GWAS) using metabolite concentrations as proxies for enzymatic activity, suggested that two variants: rs2014355 in the gene encoding short-chain acyl-coenzyme A dehydrogenase (ACADS) and rs11161510 in the gene encoding medium-chain acyl-coenzyme A dehydrogenase (ACADM) impair fatty acid β-oxidation. Chronic exposure to fatty acids due to an impaired β-oxidation may down-regulate the glucose-stimulated insulin release and result in an increased risk of type 2 diabetes (T2D). We aimed to investigate whether the two variants associate with altered insulin release following an oral glucose load or with T2D.",

keywords = "Adult, Alleles, Blood Glucose, Butyryl-CoA Dehydrogenase, Case-Control Studies, Clinical Trials as Topic, Cohort Studies, Diabetes Mellitus, Type 2, Female, Glucose Tolerance Test, Humans, Insulin, Male, Middle Aged, Prevalence",

author = "Malene Hornbak and Karina Banasik and Justesen, {Johanne Marie} and Krarup, {Nikolaj Thure} and Sandholt, {Camilla Helene} and {\AA}sa Andersson and Annelli Sandb{\ae}k and Torsten Lauritzen and Charlotta Pisinger and Witte, {Daniel Rinse} and S{\o}rensen, {Thorkild Ingvor A} and Pedersen, {Oluf Borbye} and Torben Hansen",

year = "2011",

doi = "10.1186/1471-2350-12-4",

language = "English",

volume = "12",

pages = "4",

journal = "B M C Medical Genetics",

issn = "1471-2350",

publisher = "BioMed Central Ltd",

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TY - JOUR

T1 - The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load

AU - Hornbak, Malene

AU - Banasik, Karina

AU - Justesen, Johanne Marie

AU - Krarup, Nikolaj Thure

AU - Sandholt, Camilla Helene

AU - Andersson, Åsa

AU - Sandbæk, Annelli

AU - Lauritzen, Torsten

AU - Pisinger, Charlotta

AU - Witte, Daniel Rinse

AU - Sørensen, Thorkild Ingvor A

AU - Pedersen, Oluf Borbye

AU - Hansen, Torben

PY - 2011

Y1 - 2011

N2 - A genome-wide association study (GWAS) using metabolite concentrations as proxies for enzymatic activity, suggested that two variants: rs2014355 in the gene encoding short-chain acyl-coenzyme A dehydrogenase (ACADS) and rs11161510 in the gene encoding medium-chain acyl-coenzyme A dehydrogenase (ACADM) impair fatty acid β-oxidation. Chronic exposure to fatty acids due to an impaired β-oxidation may down-regulate the glucose-stimulated insulin release and result in an increased risk of type 2 diabetes (T2D). We aimed to investigate whether the two variants associate with altered insulin release following an oral glucose load or with T2D.

AB - A genome-wide association study (GWAS) using metabolite concentrations as proxies for enzymatic activity, suggested that two variants: rs2014355 in the gene encoding short-chain acyl-coenzyme A dehydrogenase (ACADS) and rs11161510 in the gene encoding medium-chain acyl-coenzyme A dehydrogenase (ACADM) impair fatty acid β-oxidation. Chronic exposure to fatty acids due to an impaired β-oxidation may down-regulate the glucose-stimulated insulin release and result in an increased risk of type 2 diabetes (T2D). We aimed to investigate whether the two variants associate with altered insulin release following an oral glucose load or with T2D.

KW - Adult

KW - Alleles

KW - Blood Glucose

KW - Butyryl-CoA Dehydrogenase

KW - Case-Control Studies

KW - Clinical Trials as Topic

KW - Cohort Studies

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Glucose Tolerance Test

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

KW - Prevalence

U2 - 10.1186/1471-2350-12-4

DO - 10.1186/1471-2350-12-4

M3 - Journal article

C2 - 21211036

SN - 1471-2350

VL - 12

SP - 4

JO - B M C Medical Genetics

JF - B M C Medical Genetics

ER -

The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load

Abstract

Keywords

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