The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1

M G A van Eupen; M T Schram; H M Colhoun; N M J Hanssen; H W M Niessen; Lise Tarnow; H H Parving; Pia Rossing; C D A Stehouwer; C G Schalkwijk

doi:10.1007/s00125-013-2919-8

The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1

M G A van Eupen, M T Schram, H M Colhoun, N M J Hanssen, H W M Niessen, Lise Tarnow, H H Parving, Pia Rossing, C D A Stehouwer, C G Schalkwijk

46 Citations (Scopus)

Abstract

Methylglyoxal (MGO) is a major precursor for advanced glycation end-products (AGEs), which are thought to play a role in vascular complications in diabetes. Known MGO-arginine-derived AGEs are 5-hydro-5-methylimidazolone (MG-H1), argpyrimidine and tetrahydropyrimidine (THP). We studied THP in relation to type 1 diabetes, endothelial dysfunction, low-grade inflammation, vascular complications and atherosclerosis.

Original language	English
Journal	Diabetologia
Volume	56
Issue number	8
Pages (from-to)	1845-55
Number of pages	11
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-013-2919-8
Publication status	Published - Aug 2013

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van Eupen, M. G. A., Schram, M. T., Colhoun, H. M., Hanssen, N. M. J., Niessen, H. W. M., Tarnow, L., Parving, H. H., Rossing, P., Stehouwer, C. D. A., & Schalkwijk, C. G. (2013). The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1. Diabetologia, 56(8), 1845-55. https://doi.org/10.1007/s00125-013-2919-8

The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1. / van Eupen, M G A; Schram, M T; Colhoun, H M et al.
In: Diabetologia, Vol. 56, No. 8, 08.2013, p. 1845-55.

Research output: Contribution to journal › Journal article › Research › peer-review

van Eupen, MGA, Schram, MT, Colhoun, HM, Hanssen, NMJ, Niessen, HWM, Tarnow, L, Parving, HH, Rossing, P, Stehouwer, CDA & Schalkwijk, CG 2013, 'The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1', Diabetologia, vol. 56, no. 8, pp. 1845-55. https://doi.org/10.1007/s00125-013-2919-8

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abstract = "Methylglyoxal (MGO) is a major precursor for advanced glycation end-products (AGEs), which are thought to play a role in vascular complications in diabetes. Known MGO-arginine-derived AGEs are 5-hydro-5-methylimidazolone (MG-H1), argpyrimidine and tetrahydropyrimidine (THP). We studied THP in relation to type 1 diabetes, endothelial dysfunction, low-grade inflammation, vascular complications and atherosclerosis.",

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doi = "10.1007/s00125-013-2919-8",

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AU - van Eupen, M G A

AU - Schram, M T

AU - Colhoun, H M

AU - Hanssen, N M J

AU - Niessen, H W M

AU - Tarnow, Lise

AU - Parving, H H

AU - Rossing, Pia

AU - Stehouwer, C D A

AU - Schalkwijk, C G

PY - 2013/8

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AB - Methylglyoxal (MGO) is a major precursor for advanced glycation end-products (AGEs), which are thought to play a role in vascular complications in diabetes. Known MGO-arginine-derived AGEs are 5-hydro-5-methylimidazolone (MG-H1), argpyrimidine and tetrahydropyrimidine (THP). We studied THP in relation to type 1 diabetes, endothelial dysfunction, low-grade inflammation, vascular complications and atherosclerosis.

UR - https://www.scopus.com/pages/publications/84879993701

U2 - 10.1007/s00125-013-2919-8

DO - 10.1007/s00125-013-2919-8

M3 - Journal article

C2 - 23620061

SN - 0012-186X

VL - 56

SP - 1845

EP - 1855

JO - Diabetologia

JF - Diabetologia

IS - 8

ER -

The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1

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