The malaria vaccine candidate GMZ2 elicits functional antibodies in individuals from malaria endemic and non-endemic areas

Micha Phill Grønholm Jepsen; Prajakta S Jogdand; Susheel K  Singh; Meral Esen; Michael Christiansen; Saadou Issifou; Aurore B Hounkpatin; Ulysse Ateba-Ngoa; Peter G Kremsner; Morten H Dziegiel; Severin  Olesen-Larsen; Søren  Jepsen; Benjamin Mordmüller; Michael Theisen

doi:10.1093/infdis/jit185

The malaria vaccine candidate GMZ2 elicits functional antibodies in individuals from malaria endemic and non-endemic areas

Micha Phill Grønholm Jepsen, Prajakta S Jogdand, Susheel K Singh, Meral Esen, Michael Christiansen, Saadou Issifou, Aurore B Hounkpatin, Ulysse Ateba-Ngoa, Peter G Kremsner, Morten H Dziegiel, Severin Olesen-Larsen, Søren Jepsen, Benjamin Mordmüller, Michael Theisen

Clinical Immunology

56 Citations (Scopus)

Abstract

GMZ2 is a hybrid protein consisting of the N-terminal region of the glutamate-rich protein fused in frame to the C-terminal region of merozoite surface protein 3 (MSP3). GMZ2 formulated in Al(OH)3 has been tested in 3 published phase 1 clinical trials. The GMZ2/alum formulation showed good safety, tolerability, and immunogenicity, but whether antibodies elicited by vaccination are functional is not known.

Original language	English
Journal	The Internet Journal of Infectious Diseases
Volume	208
Issue number	3
Pages (from-to)	479-88
Number of pages	10
ISSN	1528-8366
DOIs	https://doi.org/10.1093/infdis/jit185
Publication status	Published - 1 Aug 2013

Keywords

Adjuvants, Immunologic
Adult
Aluminum Hydroxide
Antibodies, Protozoan
Child, Preschool
Humans
Immunoglobulin G
Malaria Vaccines
Malaria, Falciparum
Plasmodium falciparum
Vaccines, Synthetic

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Jepsen, M. P. G., Jogdand, P. S., Singh, S. K., Esen, M., Christiansen, M., Issifou, S., Hounkpatin, A. B., Ateba-Ngoa, U., Kremsner, P. G., Dziegiel, M. H., Olesen-Larsen, S., Jepsen, S., Mordmüller, B., & Theisen, M. (2013). The malaria vaccine candidate GMZ2 elicits functional antibodies in individuals from malaria endemic and non-endemic areas. The Internet Journal of Infectious Diseases, 208(3), 479-88. https://doi.org/10.1093/infdis/jit185

The malaria vaccine candidate GMZ2 elicits functional antibodies in individuals from malaria endemic and non-endemic areas. / Jepsen, Micha Phill Grønholm; Jogdand, Prajakta S; Singh, Susheel K et al.

In: The Internet Journal of Infectious Diseases, Vol. 208, No. 3, 01.08.2013, p. 479-88.

Research output: Contribution to journal › Journal article › Research › peer-review

Jepsen, MPG, Jogdand, PS, Singh, SK, Esen, M, Christiansen, M, Issifou, S, Hounkpatin, AB, Ateba-Ngoa, U, Kremsner, PG, Dziegiel, MH, Olesen-Larsen, S, Jepsen, S, Mordmüller, B & Theisen, M 2013, 'The malaria vaccine candidate GMZ2 elicits functional antibodies in individuals from malaria endemic and non-endemic areas', The Internet Journal of Infectious Diseases, vol. 208, no. 3, pp. 479-88. https://doi.org/10.1093/infdis/jit185

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KW - Aluminum Hydroxide

KW - Antibodies, Protozoan

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KW - Immunoglobulin G

KW - Malaria Vaccines

KW - Malaria, Falciparum

KW - Plasmodium falciparum

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The malaria vaccine candidate GMZ2 elicits functional antibodies in individuals from malaria endemic and non-endemic areas

Abstract

Keywords

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