Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The Ki-67 Proliferation Index as a Marker of Time to Recurrence in Intracranial Meningioma

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Letter: Enhanced Recovery After Neurosurgery for Brain Tumors - A Critical Reappraisal

    Research output: Contribution to journalLetterResearchpeer-review

  2. Laser Ablation of Abnormal Neurological Tissue Using Robotic Neuroblate System (LAANTERN): Procedural Safety and Hospitalization

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Long-Term Effect of Decompressive Craniectomy on Intracranial Pressure and Possible Implications for Intracranial Fluid Movements

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Comparison of PED and FRED Flow Diverters for Internal Carotid Artery Aneurysms: A Propensity Score-Matched Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Proposal of a new grading system for meningioma resection: the Copenhagen Protocol

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Health-Related Quality of Life and Return to Work after Surgery for Spinal Meningioma: A Population-Based Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Variations in the management of diffuse low-grade gliomas-A Scandinavian multicenter study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: There are examples of incongruence between the WHO grade and clinical course in meningioma patients. This incongruence between WHO grade and recurrence has led to search for other prognostic histological markers.

OBJECTIVE: To study the correlation between the Ki-67 proliferative index (PI), risk of recurrence, and recurrence rates in meningioma patients.

METHODS: We prospectively collected pathological diagnosis of de novo consecutive meningiomas. In total, we followed 159 patients with clinical controls until recurrence, death, or emigration. We estimated the correlation between risk of recurrence and Ki-67 PI when adjusted for age at diagnosis, sex, WHO grade, extent of surgical resection, and tumor location. We estimated the cumulative incidence of recurrence when considering death without recurrence a competing risk. We report recurrence rates per 100 person-years.

RESULTS: A 1%-point increase of Ki-67 PI yielded a hazard ratio of 1.12 (95% CI: 1.01-1.24) in a multivariate analysis. The cumulative incidence of recurrence was 3% for Ki-67 0% to 4% vs 19% for Ki-67 > 4% meningiomas after 1 yr, but 24% vs 35%, respectively, after 10 yr. There was no significant difference in mean Ki-67 PI between nonrecurrent and recurrent meningioma in a 2-sample t-test (P = .08). The strongest relationship was detected between Ki-67 PI and time to recurrence: Ki-67 < 4% meningiomas recurred after median 4.8 yr, compared to 0.60 to 0.75 yr for patients with higher Ki-67 PI.

CONCLUSION: Ki-67 PI was a marker for time to recurrence rather than a predictor of recurrence. Ki-67 PI may be utilized for patient tailored follow-up.

Original languageEnglish
JournalNeurosurgery
Volume87
Issue number6
Pages (from-to)1289-1298
Number of pages10
ISSN0069-4827
DOIs
Publication statusPublished - Dec 2020

    Research areas

  • Ki-67, Meningioma, Recurrence, Proliferative index, Brain tumor

ID: 61371894