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The Influence of Volume and Anatomic Location of Optic Disc Drusen on the Sensitivity of Autofluorescence

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  1. Optic Disc Drusen in Children: The Copenhagen Child Cohort 2000 Eye Study

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  2. Peripapillary Hyperreflective Ovoid Mass-Like Structures: Is It Optic Disc Drusen or Not?: Response

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  3. The Optic Disc Drusen Studies Consortium Recommendations for Diagnosis of Optic Disc Drusen Using Optical Coherence Tomography

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  1. Prevalence and histopathological signatures of optic disc drusen based on microscopy of 1713 enucleated eyes

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  2. Identical Horner Syndrome in Homozygotic Twins Caused by Non-Traumatic Internal Carotid Artery Dissection

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  3. The Angioarchitecture of the Optic Nerve Head in Patients with Optic Disc Drusen

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  4. An ontological foundation for ocular phenotypes and rare eye diseases

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  5. Peripapillary Ovoid Hyperreflectivity in Optic Disc Edema and Pseudopapilledema

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BACKGROUND: Optic disc drusen (ODD) are acellular deposits in the optic nerve head. ODD can be diagnosed using different imaging modalities, including enhanced depth imaging optical coherence tomography (EDI-OCT) and autofluorescence (AF). It is unknown which factors determine the sensitivity of AF. The aim of this study was to investigate the effect of volume and anatomic location of ODD on the sensitivity of AF.

METHODS: Cross-sectional study.

RESULTS: A total of 38 patients (75 eyes) with ODD were included. In 12 of 75 eyes (16%) and in 11 of 38 patients (29%), EDI-OCT detected ODD that were not detected by AF. In 24 distinctly solitary ODD, both increase in ODD volume (P = 0.0388) and a more superficial ODD location (P < 0.0001) increased the possibility of AF detection of ODD, when performing a multivariate analysis.

CONCLUSIONS: EDI-OCT is superior to AF in the diagnosis of ODD. Volume and anatomic location of ODD have a significant impact on the sensitivity of AF.

Original languageEnglish
JournalJournal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
Volume39
Issue number1
Pages (from-to)23-27
Number of pages5
ISSN1070-8022
DOIs
Publication statusPublished - 2019

ID: 56583260