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The influence of the polymorphism in apolipoprotein B codon 2488 on insulin and lipid levels in a Danish twin population

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@article{8b13952ae54f4f76bbf37c24aec1d22e,
title = "The influence of the polymorphism in apolipoprotein B codon 2488 on insulin and lipid levels in a Danish twin population",
abstract = "AIMS: The apolipoprotein B codon 2488 polymorphism has been associated with the metabolism of lipoproteins in subjects with Type 2 diabetes. However, no data are available on the influence of the polymorphism on insulin or glucose metabolism. This study examines the impact of the polymorphism on parameters associated with the insulin resistance syndrome in Danish twins. METHODS: The effect of the polymorphism on lipid, glucose and insulin measures was studied in 548 same sex twins aged 55-74 years. RESULTS: The codon 2488 polymorphism influenced fasting triglyceride levels, as well as insulin, as measured at 120 min in an oral glucose tolerance test. Subjects with the genotype T2488T had 14{\%} higher triglyceride levels (P = 0.02) and 31{\%} higher insulin levels (P = 0.004) than subjects with genotype C2488C. In twins discordant for genotype, the T-allele was associated with higher levels of triglyceride (P = 0.04) and insulin (P = 0.02) and lower levels of HDL-cholesterol (P = 0.04). CONCLUSION: The T-allele of the codon 2488 polymorphism influenced parameters related to the insulin resistance syndrome, i.e. increased levels of insulin, increased levels of triglyceride and decreased levels of HDL. As the polymorphism is silent, these effects must be mediated through linkage to other polymorphisms in apolipoprotein B or other genes on chromosome 2.",
keywords = "Aged, Apolipoproteins B, Body Mass Index, Cholesterol, Cholesterol, HDL, Cholesterol, LDL, Codon, Denmark, Diabetes Mellitus, Type 2, Female, Humans, Insulin, Lipids, Male, Middle Aged, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Triglycerides, Twins, Dizygotic, Twins, Monozygotic",
author = "J Bentzen and P Poulsen and A Vaag and H Beck-Nielsen and M Fenger",
year = "2002",
language = "English",
volume = "19",
pages = "12--8",
journal = "Diabet Med",
issn = "0742-3071",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - The influence of the polymorphism in apolipoprotein B codon 2488 on insulin and lipid levels in a Danish twin population

AU - Bentzen, J

AU - Poulsen, P

AU - Vaag, A

AU - Beck-Nielsen, H

AU - Fenger, M

PY - 2002

Y1 - 2002

N2 - AIMS: The apolipoprotein B codon 2488 polymorphism has been associated with the metabolism of lipoproteins in subjects with Type 2 diabetes. However, no data are available on the influence of the polymorphism on insulin or glucose metabolism. This study examines the impact of the polymorphism on parameters associated with the insulin resistance syndrome in Danish twins. METHODS: The effect of the polymorphism on lipid, glucose and insulin measures was studied in 548 same sex twins aged 55-74 years. RESULTS: The codon 2488 polymorphism influenced fasting triglyceride levels, as well as insulin, as measured at 120 min in an oral glucose tolerance test. Subjects with the genotype T2488T had 14% higher triglyceride levels (P = 0.02) and 31% higher insulin levels (P = 0.004) than subjects with genotype C2488C. In twins discordant for genotype, the T-allele was associated with higher levels of triglyceride (P = 0.04) and insulin (P = 0.02) and lower levels of HDL-cholesterol (P = 0.04). CONCLUSION: The T-allele of the codon 2488 polymorphism influenced parameters related to the insulin resistance syndrome, i.e. increased levels of insulin, increased levels of triglyceride and decreased levels of HDL. As the polymorphism is silent, these effects must be mediated through linkage to other polymorphisms in apolipoprotein B or other genes on chromosome 2.

AB - AIMS: The apolipoprotein B codon 2488 polymorphism has been associated with the metabolism of lipoproteins in subjects with Type 2 diabetes. However, no data are available on the influence of the polymorphism on insulin or glucose metabolism. This study examines the impact of the polymorphism on parameters associated with the insulin resistance syndrome in Danish twins. METHODS: The effect of the polymorphism on lipid, glucose and insulin measures was studied in 548 same sex twins aged 55-74 years. RESULTS: The codon 2488 polymorphism influenced fasting triglyceride levels, as well as insulin, as measured at 120 min in an oral glucose tolerance test. Subjects with the genotype T2488T had 14% higher triglyceride levels (P = 0.02) and 31% higher insulin levels (P = 0.004) than subjects with genotype C2488C. In twins discordant for genotype, the T-allele was associated with higher levels of triglyceride (P = 0.04) and insulin (P = 0.02) and lower levels of HDL-cholesterol (P = 0.04). CONCLUSION: The T-allele of the codon 2488 polymorphism influenced parameters related to the insulin resistance syndrome, i.e. increased levels of insulin, increased levels of triglyceride and decreased levels of HDL. As the polymorphism is silent, these effects must be mediated through linkage to other polymorphisms in apolipoprotein B or other genes on chromosome 2.

KW - Aged

KW - Apolipoproteins B

KW - Body Mass Index

KW - Cholesterol

KW - Cholesterol, HDL

KW - Cholesterol, LDL

KW - Codon

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Insulin

KW - Lipids

KW - Male

KW - Middle Aged

KW - Polymorphism, Genetic

KW - Polymorphism, Single Nucleotide

KW - Triglycerides

KW - Twins, Dizygotic

KW - Twins, Monozygotic

M3 - Journal article

VL - 19

SP - 12

EP - 18

JO - Diabet Med

JF - Diabet Med

SN - 0742-3071

IS - 1

ER -

ID: 32525016