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The influence of insulin on the raised plasma fibronectin concentration in human obesity

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@article{fe85dc24e90d49968f5e30711744dde4,
title = "The influence of insulin on the raised plasma fibronectin concentration in human obesity",
abstract = "Plasma concentrations of fibronectin, free insulin, C-peptide and plasma glucose were determined in 40 morbidly obese subjects and in 51 normal weight controls, matched for sex and age. All plasma concentrations were significantly elevated (p less than 0.01) among the obese subjects. A significant correlation (r = 0.34, p less than 0.05) between plasma fibronectin and plasma free insulin was found among the obese patients, but not among the controls (r = -0.02, p greater than 0.05). No significant correlation was found between plasma fibronectin and plasma C-peptide, neither in the obese patients nor in the controls (obese r = 0.06, controls r = 0.02; p greater than 0.05). Plasma fibronectin was insignificantly correlated with body weight (obese r = 0.21, controls r = 0.15; p greater than 0.05) and percentage overweight (obese r = 0.27, controls r = 0.04; p greater than 0.05). The raised level of circulating insulin may in part explain the excess of plasma fibronectin obese subjects.",
keywords = "Adult, Blood Glucose, C-Peptide, Female, Fibronectins, Humans, Insulin, Male, Middle Aged, Obesity, Obesity, Morbid",
author = "A Dejg{\aa}rd and T Andersen and C Gluud",
year = "1986",
language = "English",
volume = "220",
pages = "269--72",
journal = "Acta Medica Scandinavica, Supplement",
issn = "0365-463X",
publisher = "Almgvist & Wiksells",
number = "3",

}

RIS

TY - JOUR

T1 - The influence of insulin on the raised plasma fibronectin concentration in human obesity

AU - Dejgård, A

AU - Andersen, T

AU - Gluud, C

PY - 1986

Y1 - 1986

N2 - Plasma concentrations of fibronectin, free insulin, C-peptide and plasma glucose were determined in 40 morbidly obese subjects and in 51 normal weight controls, matched for sex and age. All plasma concentrations were significantly elevated (p less than 0.01) among the obese subjects. A significant correlation (r = 0.34, p less than 0.05) between plasma fibronectin and plasma free insulin was found among the obese patients, but not among the controls (r = -0.02, p greater than 0.05). No significant correlation was found between plasma fibronectin and plasma C-peptide, neither in the obese patients nor in the controls (obese r = 0.06, controls r = 0.02; p greater than 0.05). Plasma fibronectin was insignificantly correlated with body weight (obese r = 0.21, controls r = 0.15; p greater than 0.05) and percentage overweight (obese r = 0.27, controls r = 0.04; p greater than 0.05). The raised level of circulating insulin may in part explain the excess of plasma fibronectin obese subjects.

AB - Plasma concentrations of fibronectin, free insulin, C-peptide and plasma glucose were determined in 40 morbidly obese subjects and in 51 normal weight controls, matched for sex and age. All plasma concentrations were significantly elevated (p less than 0.01) among the obese subjects. A significant correlation (r = 0.34, p less than 0.05) between plasma fibronectin and plasma free insulin was found among the obese patients, but not among the controls (r = -0.02, p greater than 0.05). No significant correlation was found between plasma fibronectin and plasma C-peptide, neither in the obese patients nor in the controls (obese r = 0.06, controls r = 0.02; p greater than 0.05). Plasma fibronectin was insignificantly correlated with body weight (obese r = 0.21, controls r = 0.15; p greater than 0.05) and percentage overweight (obese r = 0.27, controls r = 0.04; p greater than 0.05). The raised level of circulating insulin may in part explain the excess of plasma fibronectin obese subjects.

KW - Adult

KW - Blood Glucose

KW - C-Peptide

KW - Female

KW - Fibronectins

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

KW - Obesity

KW - Obesity, Morbid

M3 - Journal article

VL - 220

SP - 269

EP - 272

JO - Acta Medica Scandinavica, Supplement

JF - Acta Medica Scandinavica, Supplement

SN - 0365-463X

IS - 3

ER -

ID: 38931043