Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The inflamed sputum in lower respiratory tract infection: l-lactate levels are correlated to neutrophil accumulation

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Epigenetic therapy in hematological cancers

    Research output: Contribution to journalReviewResearchpeer-review

  2. Subtyping of intraductal papillary mucinous neoplasms - pitfalls of MUC1 immunohistochemistry

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Mycobacterium brisbanense lung infection facilitated by steroid induced adrenal insufficiency

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Comparison of methods for measuring antibiotic consumption in an intensive care unit

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The importance of early diagnosis of Mycobacterium abscessus complex in patients with cystic fibrosis

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

Lower respiratory tract infections (LRTI) are common, but little is known about the response of biomarkers of inflammation in the lungs. Therefore, our primary aim was to compare the concentration of l-lactate to the concentration of neutrophils in sputum and systemic markers of infection. Because it is difficult to differentiate viral and bacterial infection on the basis of clinical presentation in LRTI, our secondary aim was to evaluate if l- and d-lactate may serve as markers of local inflammation as representatives of neutrophils and bacteria, respectively.

METHODS: Patients with acute LRTI were prospectively recruited. Sputum samples were collected and analysed for neutrophil count, l-lactate and d-lactate. We had data on pathogens from sputum cultures and polymerase chain reaction (PCR) (atypical bacteria, virus) and C-reactive protein (CRP) from blood.

RESULTS: In 44 sputum samples from 32 patients, the median (interquartile range (IQR)) sputum neutrophil granulocyte count was 0.615 × 107 cells/mL (0.236-1.575). The sputum neutrophil granulocyte count was associated with sputum l-lactate (p = 0.011) and CRP (p = 0.018), but not with d-lactate (p = 0.177). There was a strong association between sputum d-lactate and l-lactate (p < 0.0001).

CONCLUSION: As l-lactate in sputum is closely correlated to sequestration of neutrophils in the lungs, l-lactate is a marker for local inflammation in LRTI and a potential biomarker in clinical management of LRTI. On expectorated sputum, d-lactate had no clinical relevance.

Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume127
Issue number2
Pages (from-to)72-79
ISSN0903-4641
DOIs
Publication statusPublished - 2019

ID: 56133439