The impact of treatment density and molecular weight for fractional laser-assisted drug delivery

Christina S Haak; Brijesh Bhayana; William A Farinelli; R Rox Anderson; Merete Haedersdal

doi:10.1016/j.jconrel.2012.09.008

The impact of treatment density and molecular weight for fractional laser-assisted drug delivery

Christina S Haak, Brijesh Bhayana, William A Farinelli, R Rox Anderson, Merete Haedersdal

Department of Dermatology

51 Citations (Scopus)

Abstract

Ablative fractional lasers (AFXL) facilitate uptake of topically applied drugs by creating narrow open micro-channels into the skin, but there is limited information on optimal laser settings for delivery of specific molecules. The objective of this study was to investigate the impact of laser treatment density (% of skin occupied by channels) and molecular weight (MW) for fractional CO(2) laser-assisted drug delivery. AFXL substantially increased intra- and transcutaneous delivery of polyethylene glycols (PEGs) in a MW range from 240 to 4300 Da (Nuclear Magnetic Resonance, p

Original language	English
Journal	Journal of Controlled Release
Volume	163
Issue number	3
Pages (from-to)	335-41
Number of pages	7
ISSN	0168-3659
DOIs	https://doi.org/10.1016/j.jconrel.2012.09.008
Publication status	Published - 2012

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10.1016/j.jconrel.2012.09.008

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abstract = "Ablative fractional lasers (AFXL) facilitate uptake of topically applied drugs by creating narrow open micro-channels into the skin, but there is limited information on optimal laser settings for delivery of specific molecules. The objective of this study was to investigate the impact of laser treatment density (\% of skin occupied by channels) and molecular weight (MW) for fractional CO(2) laser-assisted drug delivery. AFXL substantially increased intra- and transcutaneous delivery of polyethylene glycols (PEGs) in a MW range from 240 to 4300 Da (Nuclear Magnetic Resonance, p",

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AU - Anderson, R Rox

AU - Haedersdal, Merete

PY - 2012

Y1 - 2012

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AB - Ablative fractional lasers (AFXL) facilitate uptake of topically applied drugs by creating narrow open micro-channels into the skin, but there is limited information on optimal laser settings for delivery of specific molecules. The objective of this study was to investigate the impact of laser treatment density (% of skin occupied by channels) and molecular weight (MW) for fractional CO(2) laser-assisted drug delivery. AFXL substantially increased intra- and transcutaneous delivery of polyethylene glycols (PEGs) in a MW range from 240 to 4300 Da (Nuclear Magnetic Resonance, p

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DO - 10.1016/j.jconrel.2012.09.008

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The impact of treatment density and molecular weight for fractional laser-assisted drug delivery

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