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The impact of early and successful orchidopexy on hormonal follow-up for 208 boys with bilateral non-syndromic cryptorchidism

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  2. Gonocyte transformation in congenital undescended testes: what is the role of inhibin-B in cell death?

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  3. The relation of germ cells per tubule in testes, serum inhibin B and FSH in cryptorchid boys

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  4. Is infertility after surgery for cryptorchidism congenital or acquired?

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  5. The incidence of maldescended testes in Denmark

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  2. PREVALENCE OF SARS-COV-2-ANTIBODIES IN DANISH CHILDREN AND ADULTS

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  3. Characteristics of Danish children registered with and pharmacologically treated for hypertension

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  4. Fertility Potential is Impaired in Boys with Bilateral Ascending Testes

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PURPOSE: Inhibin-B is produced by Sertoli cells and decreased values might be associated with impaired fertility potential. The aim of the study was to evaluate the impact of bilateral orchidopexy on serum inhibin-B and follicle-stimulating hormone (FSH).

METHODS: A cohort study including 208 bilateral cryptorchid boys (median age: 1.7 year) was evaluated with serum inhibin-B and FSH in relation to histological parameters. Based on the fertility potential, the boys were divided into three subgroups. At follow-up (median age: 2.7 years) the boys were evaluated with FSH and in case of inhibin-B using multiple of the median (MoM).

RESULTS: Inhibin-B MoM improved significantly at follow-up. In 32 boys with high FSH at orchidopexy 63% normalized FSH and 59% increased MoM inhibin-B, but 31% had impaired inhibin-B at follow-up. In 105 boys with transient hypogonadotropic hypogonadism, 52% increased inhibin-B MoM but 31% had impaired inhibin-B at follow-up. In 71 boys with normal FSH, inhibin-B, and G/T, 54% increased inhibin-B MoM and 15% had impaired inhibin-B at follow-up. The effect of the surgery was best in patients younger than 1 year.

CONCLUSION: Orchidopexy, especially before 1 year of age, improves the fertility potential in bilateral cryptorchidism. At follow-up, 26% (54/208) had a risk of infertility based on inhibin-B.

Original languageEnglish
JournalPediatric Surgery International
Volume37
Issue number3
Pages (from-to)339-345
Number of pages7
ISSN0179-0358
DOIs
Publication statusPublished - Mar 2021

    Research areas

  • Cryptorchidism, Fertility, Germ cells, Gonadotropins (FSH and LH), Inhibin B, Undescended testes

ID: 61708833