Abstract
BACKGROUND
Persons born in non-western countries have a higher risk and earlier onset of T2D in Denmark. However, it is not well investigated how country of birth status among younger adults with Type 2 Diabetes (T2D) influences the incidence of diabetes-related late complications.
OBJECTIVE
We aimed to calculate incidence rate ratios (IRR) of micro- and macrovascular complications among younger adults born in western and non-western countries compared to younger adults born in Denmark.
METHODS
Data were obtained from nationwide registries. A total of 42,926 Danish citizens diagnosed with T2D between 18-45 years (early-onset T2D: ≤45 years) were followed from 1996 to 2018 (mean follow-up: 7.6 - 9.1 years depending on complication) and classified according to country of birth as Danish, non-western or western. IRR of the first event of each complication was estimated using age and sex adjusted Poisson regression models comparing persons with T2D in relation to country of birth.
PRELIMINARY RESULTS
The average age of T2D onset was 39.24 (SD 5.7) years. 77.3% of the study population was born in Denmark, 20.2% in non-western countries and 2.5% in western countries.
In total, 10,248 (23.9%) developed cardiovascular disease (CVD), 2,147 (5%) developed retinopathy, 3,750 (8.7%) developed nephropathy, and 696 (1.6%) underwent an amputation during follow-up.
Persons born in non-western countries had an increased risk of retinopathy (IRR: 1.23 (CI: 1.11-1.35)) compared to those born in Denmark, but a decreased risk of CVD (IRR: 0.89 (95% CI: 0.85 – 0.94)), nephropathy (IRR: 0.58 (95% CI: 0.53-0.64)) and amputation (IRR: 0.33 (95% CI: 0.25-0.44)). Persons born in western countries had an increased risk of retinopathy (IRR: 1.20 (CI: 0.85-1.70)), a similar risk of nephropathy (IRR: 1.00 (95% CI: 0.75-1.35)) and a lower risk of CVD (IRR: 0.96 (95% Cl: 0.82-1.11) and amputation (IRR: 0.66 (95% CI: 0.34-1.28)) compared to those born in Denmark.
CONCLUSIONS
Persons with early-onset T2D born in non-western or western countries had a slightly higher risk of retinopathy and a lower risk of CVD and amputation compared to younger adults born in Denmark.
Persons born in non-western countries have a higher risk and earlier onset of T2D in Denmark. However, it is not well investigated how country of birth status among younger adults with Type 2 Diabetes (T2D) influences the incidence of diabetes-related late complications.
OBJECTIVE
We aimed to calculate incidence rate ratios (IRR) of micro- and macrovascular complications among younger adults born in western and non-western countries compared to younger adults born in Denmark.
METHODS
Data were obtained from nationwide registries. A total of 42,926 Danish citizens diagnosed with T2D between 18-45 years (early-onset T2D: ≤45 years) were followed from 1996 to 2018 (mean follow-up: 7.6 - 9.1 years depending on complication) and classified according to country of birth as Danish, non-western or western. IRR of the first event of each complication was estimated using age and sex adjusted Poisson regression models comparing persons with T2D in relation to country of birth.
PRELIMINARY RESULTS
The average age of T2D onset was 39.24 (SD 5.7) years. 77.3% of the study population was born in Denmark, 20.2% in non-western countries and 2.5% in western countries.
In total, 10,248 (23.9%) developed cardiovascular disease (CVD), 2,147 (5%) developed retinopathy, 3,750 (8.7%) developed nephropathy, and 696 (1.6%) underwent an amputation during follow-up.
Persons born in non-western countries had an increased risk of retinopathy (IRR: 1.23 (CI: 1.11-1.35)) compared to those born in Denmark, but a decreased risk of CVD (IRR: 0.89 (95% CI: 0.85 – 0.94)), nephropathy (IRR: 0.58 (95% CI: 0.53-0.64)) and amputation (IRR: 0.33 (95% CI: 0.25-0.44)). Persons born in western countries had an increased risk of retinopathy (IRR: 1.20 (CI: 0.85-1.70)), a similar risk of nephropathy (IRR: 1.00 (95% CI: 0.75-1.35)) and a lower risk of CVD (IRR: 0.96 (95% Cl: 0.82-1.11) and amputation (IRR: 0.66 (95% CI: 0.34-1.28)) compared to those born in Denmark.
CONCLUSIONS
Persons with early-onset T2D born in non-western or western countries had a slightly higher risk of retinopathy and a lower risk of CVD and amputation compared to younger adults born in Denmark.
| Original language | Danish |
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| Publication date | 3 Mar 2022 |
| Publication status | Published - 3 Mar 2022 |
| Event | Hverdagslivet med type 2-diabetes - Comwell - Roskilde, Roskilde, Denmark Duration: 3 Mar 2022 → 3 Mar 2022 |
Conference
| Conference | Hverdagslivet med type 2-diabetes |
|---|---|
| Location | Comwell - Roskilde |
| Country/Territory | Denmark |
| City | Roskilde |
| Period | 03/03/2022 → 03/03/2022 |