Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The impact of axon orientation dispersion and 3D diameter variations on the transverse apparent diffusion coefficient

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Links

  1. On the cortical connectivity in the macaque brain: a comparison of diffusion tractography and histological tracing data

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. 3D analysis of the myenteric plexus of the human bowel by X-ray phase-contrast tomography - a future method?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Functional and Structural Plasticity Co-express in a Left Premotor Region During Early Bimanual Skill Learning

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Streamline tractography for 3D mapping of axon bundle organization in one MRI voxel using ultra-high resolution synchrotron radiation imaging

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

View graph of relations
We extract the orientation dispersion (OD) and 3D axon diameter variations of long axons (>100 µm) from an ultra-high resolution, synchrotron X-ray nano-holotomography (XNH) scan of the monkey splenium. From this, we discover a relationship between mean axon diameter and along-axon diameter variations. Monte Carlo simulations are then performed on the intra-axonal spaces (IAS) of different substrates which inherit their morphological features from the segmented axons. These simulations show that the OD significantly affects the transverse apparent diffusion coefficient (ADC⟂) of the axon substrate at diffusion times up to 50 ms, while diameter variations do not.
Original languageEnglish
Title of host publicationProceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition
Number of pages3
PublisherThe International Society for Magnetic Resonance in Medicine
Publication dateAug 2020
Pages1-3
Article number0712
Publication statusPublished - Aug 2020
EventISMRM & SMRT Virtual Conference & Exhibition 2020 - Virtual conference
Duration: 8 Aug 202014 Aug 2020
https://www.ismrm.org/20m/

Conference

ConferenceISMRM & SMRT Virtual Conference & Exhibition 2020
LocationVirtual conference
Periode08/08/202014/08/2020
Internetadresse

Event

ISMRM & SMRT Virtual Conference & Exhibition 2020

08/08/202014/08/2020

Event: Conference

ID: 62005591