The impact of axon orientation dispersion and 3D diameter variations on the transverse apparent diffusion coefficient

Mariam Andersson; Jonathan Rafael-Patino; Hans Martin Kjer; Vedrana Andersen Dahl; Alexandra Pacureanu; Martin Bech; Anders Bjorholm Dahl; Jean-Philippe Thiran; Tim B Dyrby

The impact of axon orientation dispersion and 3D diameter variations on the transverse apparent diffusion coefficient

Mariam Andersson, Jonathan Rafael-Patino, Hans Martin Kjer, Vedrana Andersen Dahl, Alexandra Pacureanu, Martin Bech, Anders Bjorholm Dahl, Jean-Philippe Thiran, Tim B Dyrby

Abstract

We extract the orientation dispersion (OD) and 3D axon diameter variations of long axons (>100 µm) from an ultra-high resolution, synchrotron X-ray nano-holotomography (XNH) scan of the monkey splenium. From this, we discover a relationship between mean axon diameter and along-axon diameter variations. Monte Carlo simulations are then performed on the intra-axonal spaces (IAS) of different substrates which inherit their morphological features from the segmented axons. These simulations show that the OD significantly affects the transverse apparent diffusion coefficient (ADC⟂) of the axon substrate at diffusion times up to 50 ms, while diameter variations do not.

Original language	English
Title of host publication	Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition
Number of pages	3
Publisher	The International Society for Magnetic Resonance in Medicine
Publication date	Aug 2020
Pages	1-3
Article number	0712
Publication status	Published - Aug 2020
Event	ISMRM & SMRT Virtual Conference & Exhibition 2020 - Virtual conference Duration: 8 Aug 2020 → 14 Aug 2020 https://www.ismrm.org/20m/

Conference

Conference	ISMRM & SMRT Virtual Conference & Exhibition 2020
Location	Virtual conference
Period	08/08/2020 → 14/08/2020
Internet address	https://www.ismrm.org/20m/

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Andersson, M., Rafael-Patino, J., Kjer, H. M., Dahl, V. A., Pacureanu, A., Bech, M., Dahl, A. B., Thiran, J.-P., & Dyrby, T. B. (2020). The impact of axon orientation dispersion and 3D diameter variations on the transverse apparent diffusion coefficient. In Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition (pp. 1-3). Article 0712 The International Society for Magnetic Resonance in Medicine. https://archive.ismrm.org/2020/0712.html

The impact of axon orientation dispersion and 3D diameter variations on the transverse apparent diffusion coefficient. / Andersson, Mariam; Rafael-Patino, Jonathan; Kjer, Hans Martin et al.
Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition. The International Society for Magnetic Resonance in Medicine, 2020. p. 1-3 0712.

Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research › peer-review

Andersson, M, Rafael-Patino, J, Kjer, HM, Dahl, VA, Pacureanu, A, Bech, M, Dahl, AB, Thiran, J-P & Dyrby, TB 2020, The impact of axon orientation dispersion and 3D diameter variations on the transverse apparent diffusion coefficient. in Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition., 0712, The International Society for Magnetic Resonance in Medicine, pp. 1-3, ISMRM & SMRT Virtual Conference & Exhibition 2020, 08/08/2020. <https://archive.ismrm.org/2020/0712.html>

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title = "The impact of axon orientation dispersion and 3D diameter variations on the transverse apparent diffusion coefficient",

abstract = "We extract the orientation dispersion (OD) and 3D axon diameter variations of long axons (>100 µm) from an ultra-high resolution, synchrotron X-ray nano-holotomography (XNH) scan of the monkey splenium. From this, we discover a relationship between mean axon diameter and along-axon diameter variations. Monte Carlo simulations are then performed on the intra-axonal spaces (IAS) of different substrates which inherit their morphological features from the segmented axons. These simulations show that the OD significantly affects the transverse apparent diffusion coefficient (ADC⟂) of the axon substrate at diffusion times up to 50 ms, while diameter variations do not.",

author = "Mariam Andersson and Jonathan Rafael-Patino and Kjer, {Hans Martin} and Dahl, {Vedrana Andersen} and Alexandra Pacureanu and Martin Bech and Dahl, {Anders Bjorholm} and Jean-Philippe Thiran and Dyrby, {Tim B}",

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booktitle = "Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition",

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T1 - The impact of axon orientation dispersion and 3D diameter variations on the transverse apparent diffusion coefficient

AU - Andersson, Mariam

AU - Rafael-Patino, Jonathan

AU - Kjer, Hans Martin

AU - Dahl, Vedrana Andersen

AU - Pacureanu, Alexandra

AU - Bech, Martin

AU - Dahl, Anders Bjorholm

AU - Thiran, Jean-Philippe

AU - Dyrby, Tim B

PY - 2020/8

Y1 - 2020/8

N2 - We extract the orientation dispersion (OD) and 3D axon diameter variations of long axons (>100 µm) from an ultra-high resolution, synchrotron X-ray nano-holotomography (XNH) scan of the monkey splenium. From this, we discover a relationship between mean axon diameter and along-axon diameter variations. Monte Carlo simulations are then performed on the intra-axonal spaces (IAS) of different substrates which inherit their morphological features from the segmented axons. These simulations show that the OD significantly affects the transverse apparent diffusion coefficient (ADC⟂) of the axon substrate at diffusion times up to 50 ms, while diameter variations do not.

AB - We extract the orientation dispersion (OD) and 3D axon diameter variations of long axons (>100 µm) from an ultra-high resolution, synchrotron X-ray nano-holotomography (XNH) scan of the monkey splenium. From this, we discover a relationship between mean axon diameter and along-axon diameter variations. Monte Carlo simulations are then performed on the intra-axonal spaces (IAS) of different substrates which inherit their morphological features from the segmented axons. These simulations show that the OD significantly affects the transverse apparent diffusion coefficient (ADC⟂) of the axon substrate at diffusion times up to 50 ms, while diameter variations do not.

M3 - Conference abstract in proceedings

SP - 1

EP - 3

BT - Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition

PB - The International Society for Magnetic Resonance in Medicine

T2 - ISMRM & SMRT Virtual Conference & Exhibition 2020

Y2 - 8 August 2020 through 14 August 2020

ER -

The impact of axon orientation dispersion and 3D diameter variations on the transverse apparent diffusion coefficient

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