TY - JOUR
T1 - The Human Leukocyte Antigen-G 3'UTR 14-bp Deletion is Associated with Poor Survival in an HIV-1-infected Zimbabwean Population
AU - Larsen, Margit Hørup
AU - Zinyama, Rutendo
AU - Kallestrup, Per
AU - Gerstoft, Jan
AU - Gomo, Exnevia
AU - Thørner, Lise Wegner
AU - Berg, Trine Baldorf
AU - Erikstup, Christian
AU - Ullum, Henrik
PY - 2013
Y1 - 2013
N2 - We aimed to evaluate if the HLA-G 14-bp polymorphism (rs16375) has an impact on HIV progression and survival in an antiretroviral therapy (ART)-naïve Zimbabwean cohort (n=312). Rs16375 was genotyped using a competitive allele-specific PCR system; CD4 cell counts and HIV RNA were measured by flow cytometry and commercially available PCR; survival was followed for 4.3 years. The homozygous HLA-G -14-bp genotype is associated with higher viral load (P=0.004), lower CD4 cell count (P=0.01), and increased mortality (hazard ratio=1.9, CI: 1.033-3.522; P=0.04) compared with HLA-G +14-bp carriers.
AB - We aimed to evaluate if the HLA-G 14-bp polymorphism (rs16375) has an impact on HIV progression and survival in an antiretroviral therapy (ART)-naïve Zimbabwean cohort (n=312). Rs16375 was genotyped using a competitive allele-specific PCR system; CD4 cell counts and HIV RNA were measured by flow cytometry and commercially available PCR; survival was followed for 4.3 years. The homozygous HLA-G -14-bp genotype is associated with higher viral load (P=0.004), lower CD4 cell count (P=0.01), and increased mortality (hazard ratio=1.9, CI: 1.033-3.522; P=0.04) compared with HLA-G +14-bp carriers.
U2 - 10.1093/infdis/jis924
DO - 10.1093/infdis/jis924
M3 - Journal article
C2 - 23264673
SN - 0022-1899
VL - 207
SP - 903
EP - 906
JO - The Journal of infectious diseases
JF - The Journal of infectious diseases
IS - 6
ER -