The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors

Heidi Rye Hudlebusch; Eric Santoni-Rugiu; Ronald Simon; Elisabeth Ralfkiær; Henrik Holm Rossing; Jens Vilstrup Johansen; Mette Jørgensen; Guido Sauter; Kristian Helin

doi:10.1158/1078-0432.CCR-10-1302

The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors

Heidi Rye Hudlebusch, Eric Santoni-Rugiu, Ronald Simon, Elisabeth Ralfkiær, Henrik Holm Rossing, Jens Vilstrup Johansen, Mette Jørgensen, Guido Sauter, Kristian Helin

125 Citations (Scopus)

Abstract

Multiple myeloma SET (Suppressor of variegation, Enhancer of zeste, and Trithorax) domain (MMSET) is a histone lysine methyltransferase deregulated in a subgroup of multiple myelomas with the t(4;14)(p16;q32) translocation and poor prognosis. With the aim of understanding, if MMSET can be involved in other types of cancer we investigated the expression of MMSET protein in different types of human tumors.

Original language	English
Journal	Clinical Cancer Research
Volume	17
Issue number	9
Pages (from-to)	2919-33
Number of pages	15
ISSN	1078-0432
DOIs	https://doi.org/10.1158/1078-0432.CCR-10-1302
Publication status	Published - 2011

Keywords

Animals
Antibodies, Monoclonal
Antibody Specificity
Female
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Histone-Lysine N-Methyltransferase
Humans
Male
Mice
Models, Biological
Neoplasms
Oncogene Proteins
Repressor Proteins
Tissue Array Analysis
Tumor Cells, Cultured
Up-Regulation

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10.1158/1078-0432.CCR-10-1302

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title = "The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors",

abstract = "Multiple myeloma SET (Suppressor of variegation, Enhancer of zeste, and Trithorax) domain (MMSET) is a histone lysine methyltransferase deregulated in a subgroup of multiple myelomas with the t(4;14)(p16;q32) translocation and poor prognosis. With the aim of understanding, if MMSET can be involved in other types of cancer we investigated the expression of MMSET protein in different types of human tumors.",

keywords = "Animals, Antibodies, Monoclonal, Antibody Specificity, Female, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Histone-Lysine N-Methyltransferase, Humans, Male, Mice, Models, Biological, Neoplasms, Oncogene Proteins, Repressor Proteins, Tissue Array Analysis, Tumor Cells, Cultured, Up-Regulation",

author = "Hudlebusch, \{Heidi Rye\} and Eric Santoni-Rugiu and Ronald Simon and Elisabeth Ralfki{\ae}r and Rossing, \{Henrik Holm\} and Johansen, \{Jens Vilstrup\} and Mette J{\o}rgensen and Guido Sauter and Kristian Helin",

note = "{\textcopyright}2011 AACR.",

year = "2011",

doi = "10.1158/1078-0432.CCR-10-1302",

language = "English",

volume = "17",

pages = "2919--33",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

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TY - JOUR

T1 - The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors

AU - Hudlebusch, Heidi Rye

AU - Santoni-Rugiu, Eric

AU - Simon, Ronald

AU - Ralfkiær, Elisabeth

AU - Rossing, Henrik Holm

AU - Johansen, Jens Vilstrup

AU - Jørgensen, Mette

AU - Sauter, Guido

AU - Helin, Kristian

PY - 2011

Y1 - 2011

N2 - Multiple myeloma SET (Suppressor of variegation, Enhancer of zeste, and Trithorax) domain (MMSET) is a histone lysine methyltransferase deregulated in a subgroup of multiple myelomas with the t(4;14)(p16;q32) translocation and poor prognosis. With the aim of understanding, if MMSET can be involved in other types of cancer we investigated the expression of MMSET protein in different types of human tumors.

AB - Multiple myeloma SET (Suppressor of variegation, Enhancer of zeste, and Trithorax) domain (MMSET) is a histone lysine methyltransferase deregulated in a subgroup of multiple myelomas with the t(4;14)(p16;q32) translocation and poor prognosis. With the aim of understanding, if MMSET can be involved in other types of cancer we investigated the expression of MMSET protein in different types of human tumors.

KW - Animals

KW - Antibodies, Monoclonal

KW - Antibody Specificity

KW - Female

KW - Gene Expression Regulation, Enzymologic

KW - Gene Expression Regulation, Neoplastic

KW - Histone-Lysine N-Methyltransferase

KW - Humans

KW - Male

KW - Mice

KW - Models, Biological

KW - Neoplasms

KW - Oncogene Proteins

KW - Repressor Proteins

KW - Tissue Array Analysis

KW - Tumor Cells, Cultured

KW - Up-Regulation

UR - https://www.scopus.com/pages/publications/79955506975

U2 - 10.1158/1078-0432.CCR-10-1302

DO - 10.1158/1078-0432.CCR-10-1302

M3 - Journal article

C2 - 21385930

SN - 1078-0432

VL - 17

SP - 2919

EP - 2933

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 9

ER -

The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors

Abstract

Keywords

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