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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The high-risk plaque initiative: primary prevention of atherothrombotic events in the asymptomatic population

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  1. Coronary Microvascular Dysfunction: A Practical Approach to Diagnosis and Management

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  2. Genetics of Lipoprotein(a): Cardiovascular Disease and Future Therapy

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  3. Antisense Oligonucleotides Targeting Lipoprotein(a)

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  4. Peripheral Arterial Disease in Women: an Overview of Risk Factor Profile, Clinical Features, and Outcomes

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  5. Non-invasive imaging for subclinical coronary atherosclerosis in patients with peripheral artery disease

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  1. Carotid plaque thickness is increased in chronic kidney disease and associated with carotid and coronary calcification

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  2. The Short-term Predictive Value of Vessel Wall Stiffness on Abdominal Aortic Aneurysm Growth

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  3. Three-dimensional ultrasound improves identification of patients with abdominal aortic aneurysms reaching the threshold for repair

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The High-Risk Plaque (HRP) Initiative is a research and development effort to advance the understanding, recognition, and management of asymptomatic individuals at risk for a near-term atherothrombotic event such as myocardial infarction or stroke. Clinical studies using the newest technologies have been initiated, including the BioImage Study in which novel approaches are tested in a typical health plan population. Asymptomatic at-risk individuals were enrolled, including a survey-only group (n = 865), a group undergoing traditional risk factor scoring (n = 718), and a group in which all were assessed for both risk factors and subclinical atherosclerosis (n = 6104). The latter two groups underwent baseline examination in a dedicated mobile facility equipped with advanced imaging tools suitable for noninvasive screening for subclinical atherosclerosis (coronary artery calcium by computed tomography [CT], carotid and aortic disease by ultrasound, and ankle-brachial index). Selected participants were offered advanced imaging (contrast-enhanced CT, magnetic resonance imaging, and positron emission tomography/CT). Plasma, PAXgene RNA, and DNA samples were obtained for biomarker discovery studies. All individuals will be followed until 600 major atherothrombotic events have occurred in those undergoing imaging.
Original languageEnglish
JournalCurrent Atherosclerosis Reports
Volume13
Issue number5
Pages (from-to)359-66
Number of pages8
ISSN1523-3804
DOIs
Publication statusPublished - 2011

ID: 33198341