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The glycolipid sulfatide protects insulin-producing cells against cytokine-induced apoptosis, a possible role in diabetes

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  • A Roeske-Nielsen
  • L T Dalgaard
  • Sven-Erik Månsson
  • K Buschard
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Cytokine-induced apoptosis is recognised as a major cause of the decline in β-cell mass that ultimately leads to type 1 diabetes mellitus. Interleukin-1β, interferon-γ and tumour necrosis factor-α in conjunction initiate a series of events that lead to β-cell apoptosis; important among these is NO production. The glycosphingolipid sulfatide is present in β-cells in the secretory granules in varying amounts and is secreted together with insulin. We now investigate whether sulfatide is able to protect insulin-producing cells against the pro-apoptotic effect of interleukin-1β, interferon-γ and tumour necrosis factor-α.
Original languageEnglish
JournalDiabetes - Metabolism: Research and Reviews (Print Edition)
Volume26
Issue number8
Pages (from-to)631-8
Number of pages8
ISSN1520-7552
DOIs
Publication statusPublished - 1 Nov 2010

ID: 31059823