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The global dissemination of hospital clones of Enterococcus faecium

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Harvard

van Hal, SJ, Willems, RJL, Gouliouris, T, Ballard, SA, Coque, TM, Hammerum, AM, Hegstad, K, Westh, H, Howden, BP, Malhotra-Kumar, S, Werner, G, Yanagihara, K, Earl, AM, Raven, KE, Corander, J, Bowden, R & Enterococcal Group 2021, 'The global dissemination of hospital clones of Enterococcus faecium', Genome Medicine, vol. 13, no. 1, 52, pp. 1-12. https://doi.org/10.1186/s13073-021-00868-0

APA

van Hal, S. J., Willems, R. J. L., Gouliouris, T., Ballard, S. A., Coque, T. M., Hammerum, A. M., Hegstad, K., Westh, H., Howden, B. P., Malhotra-Kumar, S., Werner, G., Yanagihara, K., Earl, A. M., Raven, K. E., Corander, J., Bowden, R., & Enterococcal Group (2021). The global dissemination of hospital clones of Enterococcus faecium. Genome Medicine, 13(1), 1-12. [52]. https://doi.org/10.1186/s13073-021-00868-0

CBE

van Hal SJ, Willems RJL, Gouliouris T, Ballard SA, Coque TM, Hammerum AM, Hegstad K, Westh H, Howden BP, Malhotra-Kumar S, Werner G, Yanagihara K, Earl AM, Raven KE, Corander J, Bowden R, Enterococcal Group. 2021. The global dissemination of hospital clones of Enterococcus faecium. Genome Medicine. 13(1):1-12. https://doi.org/10.1186/s13073-021-00868-0

MLA

Vancouver

van Hal SJ, Willems RJL, Gouliouris T, Ballard SA, Coque TM, Hammerum AM et al. The global dissemination of hospital clones of Enterococcus faecium. Genome Medicine. 2021 Mar 30;13(1):1-12. 52. https://doi.org/10.1186/s13073-021-00868-0

Author

van Hal, Sebastiaan J ; Willems, Rob J L ; Gouliouris, Theodore ; Ballard, Susan A ; Coque, Teresa M ; Hammerum, Anette M ; Hegstad, Kristin ; Westh, Hendrik ; Howden, Benjamin P ; Malhotra-Kumar, Surbhi ; Werner, Guido ; Yanagihara, Katsunori ; Earl, Ashlee M ; Raven, Katherine E ; Corander, Jukka ; Bowden, Rory ; Enterococcal Group. / The global dissemination of hospital clones of Enterococcus faecium. In: Genome Medicine. 2021 ; Vol. 13, No. 1. pp. 1-12.

Bibtex

@article{473b4b4e1f124d2ab3a39eaca022f343,
title = "The global dissemination of hospital clones of Enterococcus faecium",
abstract = "BACKGROUND: The hospital-adapted A1 group of Enterococcus faecium remains an organism of significant concern in the context of drug-resistant hospital-associated infections. How this pathogen evolves and disseminates remains poorly understood.METHODS: A large, globally representative collection of short-read genomic data from the hospital-associated A1 group of Enterococcus faecium was assembled (n = 973). We analysed, using a novel analysis approach, global diversity in terms of both the dynamics of the accessory genome and homologous recombination among conserved genes.RESULTS: Two main modes of genomic evolution continue to shape E. faecium: the acquisition and loss of genes, including antimicrobial resistance genes, through mobile genetic elements including plasmids, and homologous recombination of the core genome. These events lead to new clones emerging at the local level, followed by the erosion of signals of clonality through recombination, and in some identifiable cases producing new clonal clusters. These patterns lead to new, emerging lineages which are able to spread globally over relatively short timeframes.CONCLUSIONS: The ability of A1 E. faecium to continually present new combinations of genes for potential selection suggests that controlling this pathogen will remain challenging but establishing a framework for understanding genomic evolution is likely to aid in tracking the threats posed by newly emerging lineages.",
keywords = "Adaptation, Physiological/genetics, Anti-Bacterial Agents/pharmacology, Clone Cells, Cluster Analysis, Enterococcus faecium/drug effects, Genome, Bacterial, Hospitals, Internationality, Microbial Sensitivity Tests, Plasmids/genetics",
author = "{van Hal}, {Sebastiaan J} and Willems, {Rob J L} and Theodore Gouliouris and Ballard, {Susan A} and Coque, {Teresa M} and Hammerum, {Anette M} and Kristin Hegstad and Hendrik Westh and Howden, {Benjamin P} and Surbhi Malhotra-Kumar and Guido Werner and Katsunori Yanagihara and Earl, {Ashlee M} and Raven, {Katherine E} and Jukka Corander and Rory Bowden and {Enterococcal Group}",
year = "2021",
month = mar,
day = "30",
doi = "10.1186/s13073-021-00868-0",
language = "English",
volume = "13",
pages = "1--12",
journal = "Genome Medicine",
issn = "1756-994X",
publisher = "BioMed Central Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - The global dissemination of hospital clones of Enterococcus faecium

AU - van Hal, Sebastiaan J

AU - Willems, Rob J L

AU - Gouliouris, Theodore

AU - Ballard, Susan A

AU - Coque, Teresa M

AU - Hammerum, Anette M

AU - Hegstad, Kristin

AU - Westh, Hendrik

AU - Howden, Benjamin P

AU - Malhotra-Kumar, Surbhi

AU - Werner, Guido

AU - Yanagihara, Katsunori

AU - Earl, Ashlee M

AU - Raven, Katherine E

AU - Corander, Jukka

AU - Bowden, Rory

AU - Enterococcal Group

PY - 2021/3/30

Y1 - 2021/3/30

N2 - BACKGROUND: The hospital-adapted A1 group of Enterococcus faecium remains an organism of significant concern in the context of drug-resistant hospital-associated infections. How this pathogen evolves and disseminates remains poorly understood.METHODS: A large, globally representative collection of short-read genomic data from the hospital-associated A1 group of Enterococcus faecium was assembled (n = 973). We analysed, using a novel analysis approach, global diversity in terms of both the dynamics of the accessory genome and homologous recombination among conserved genes.RESULTS: Two main modes of genomic evolution continue to shape E. faecium: the acquisition and loss of genes, including antimicrobial resistance genes, through mobile genetic elements including plasmids, and homologous recombination of the core genome. These events lead to new clones emerging at the local level, followed by the erosion of signals of clonality through recombination, and in some identifiable cases producing new clonal clusters. These patterns lead to new, emerging lineages which are able to spread globally over relatively short timeframes.CONCLUSIONS: The ability of A1 E. faecium to continually present new combinations of genes for potential selection suggests that controlling this pathogen will remain challenging but establishing a framework for understanding genomic evolution is likely to aid in tracking the threats posed by newly emerging lineages.

AB - BACKGROUND: The hospital-adapted A1 group of Enterococcus faecium remains an organism of significant concern in the context of drug-resistant hospital-associated infections. How this pathogen evolves and disseminates remains poorly understood.METHODS: A large, globally representative collection of short-read genomic data from the hospital-associated A1 group of Enterococcus faecium was assembled (n = 973). We analysed, using a novel analysis approach, global diversity in terms of both the dynamics of the accessory genome and homologous recombination among conserved genes.RESULTS: Two main modes of genomic evolution continue to shape E. faecium: the acquisition and loss of genes, including antimicrobial resistance genes, through mobile genetic elements including plasmids, and homologous recombination of the core genome. These events lead to new clones emerging at the local level, followed by the erosion of signals of clonality through recombination, and in some identifiable cases producing new clonal clusters. These patterns lead to new, emerging lineages which are able to spread globally over relatively short timeframes.CONCLUSIONS: The ability of A1 E. faecium to continually present new combinations of genes for potential selection suggests that controlling this pathogen will remain challenging but establishing a framework for understanding genomic evolution is likely to aid in tracking the threats posed by newly emerging lineages.

KW - Adaptation, Physiological/genetics

KW - Anti-Bacterial Agents/pharmacology

KW - Clone Cells

KW - Cluster Analysis

KW - Enterococcus faecium/drug effects

KW - Genome, Bacterial

KW - Hospitals

KW - Internationality

KW - Microbial Sensitivity Tests

KW - Plasmids/genetics

UR - http://www.scopus.com/inward/record.url?scp=85103683904&partnerID=8YFLogxK

U2 - 10.1186/s13073-021-00868-0

DO - 10.1186/s13073-021-00868-0

M3 - Journal article

C2 - 33785076

VL - 13

SP - 1

EP - 12

JO - Genome Medicine

JF - Genome Medicine

SN - 1756-994X

IS - 1

M1 - 52

ER -

ID: 68198412