The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

Isabelle Bos; Stephanie J Vos; Lutz Frölich; Johannes Kornhuber; Jens Wiltfang; Wolfgang Maier; Oliver Peters; Eckhart Rüther; Sebastiaan Engelborghs; Ellis Niemantsverdriet; Ellen Elisa De Roeck; Magda Tsolaki; Yvonne Freund-Levi; Peter Johannsen; Rik Vandenberghe; Alberto Lleó; Daniel Alcolea; Giovanni B Frisoni; Samantha Galluzzi; Flavio Nobili; Silvia Morbelli; Alexander Drzezga; Mira Didic; Bart N van Berckel; Eric Salmon; Christine Bastin; Solene Dauby; Isabel Santana; Inês Baldeiras; Alexandre de Mendonça; Dina Silva; Anders Wallin; Arto Nordlund; Preciosa M Coloma; Angelika Wientzek; Myriam Alexander; Gerald P Novak; Mark Forrest Gordon; Åsa K Wallin; Harald Hampel; Hilkka Soininen; Sanna-Kaisa Herukka; Philip Scheltens; Frans R Verhey; Pieter Jelle Visser; Alzheimer’s Disease Neuroimaging Initiative (ADNI)

doi:10.1016/j.neurobiolaging.2017.03.034

The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

Isabelle Bos, Stephanie J Vos, Lutz Frölich, Johannes Kornhuber, Jens Wiltfang, Wolfgang Maier, Oliver Peters, Eckhart Rüther, Sebastiaan Engelborghs, Ellis Niemantsverdriet, Ellen Elisa De Roeck, Magda Tsolaki, Yvonne Freund-Levi, Peter Johannsen, Rik Vandenberghe, Alberto Lleó, Daniel Alcolea, Giovanni B Frisoni, Samantha Galluzzi, Flavio NobiliSilvia Morbelli, Alexander Drzezga, Mira Didic, Bart N van Berckel, Eric Salmon, Christine Bastin, Solene Dauby, Isabel Santana, Inês Baldeiras, Alexandre de Mendonça, Dina Silva, Anders Wallin, Arto Nordlund, Preciosa M Coloma, Angelika Wientzek, Myriam Alexander, Gerald P Novak, Mark Forrest Gordon, Åsa K Wallin, Harald Hampel, Hilkka Soininen, Sanna-Kaisa Herukka, Philip Scheltens, Frans R Verhey, Pieter Jelle Visser, Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Department of Neurology

24 Citations (Scopus)

Abstract

We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.

Original language	English
Journal	Neurobiology of Aging
Volume	56
Pages (from-to)	33-40
Number of pages	8
ISSN	0197-4580
DOIs	https://doi.org/10.1016/j.neurobiolaging.2017.03.034
Publication status	Published - Aug 2017

Keywords

Aged
Alcohol Drinking
Alzheimer Disease
Biomarkers
Cognition
Cognitive Dysfunction
Depression
Disease Progression
Female
Humans
Hypercholesterolemia
Male
Middle Aged
Obesity
Proportional Hazards Models
Risk Factors
Journal Article

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10.1016/j.neurobiolaging.2017.03.034

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Bos, I., Vos, S. J., Frölich, L., Kornhuber, J., Wiltfang, J., Maier, W., Peters, O., Rüther, E., Engelborghs, S., Niemantsverdriet, E., De Roeck, E. E., Tsolaki, M., Freund-Levi, Y., Johannsen, P., Vandenberghe, R., Lleó, A., Alcolea, D., Frisoni, G. B., Galluzzi, S., ... Alzheimer’s Disease Neuroimaging Initiative (ADNI) (2017). The frequency and influence of dementia risk factors in prodromal Alzheimer's disease. Neurobiology of Aging, 56, 33-40. https://doi.org/10.1016/j.neurobiolaging.2017.03.034

Bos, I, Vos, SJ, Frölich, L, Kornhuber, J, Wiltfang, J, Maier, W, Peters, O, Rüther, E, Engelborghs, S, Niemantsverdriet, E, De Roeck, EE, Tsolaki, M, Freund-Levi, Y, Johannsen, P, Vandenberghe, R, Lleó, A, Alcolea, D, Frisoni, GB, Galluzzi, S, Nobili, F, Morbelli, S, Drzezga, A, Didic, M, van Berckel, BN, Salmon, E, Bastin, C, Dauby, S, Santana, I, Baldeiras, I, de Mendonça, A, Silva, D, Wallin, A, Nordlund, A, Coloma, PM, Wientzek, A, Alexander, M, Novak, GP, Gordon, MF, Wallin, ÅK, Hampel, H, Soininen, H, Herukka, S-K, Scheltens, P, Verhey, FR, Visser, PJ & Alzheimer’s Disease Neuroimaging Initiative (ADNI) 2017, 'The frequency and influence of dementia risk factors in prodromal Alzheimer's disease', Neurobiology of Aging, vol. 56, pp. 33-40. https://doi.org/10.1016/j.neurobiolaging.2017.03.034

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abstract = "We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.",

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author = "Isabelle Bos and Vos, {Stephanie J} and Lutz Fr{\"o}lich and Johannes Kornhuber and Jens Wiltfang and Wolfgang Maier and Oliver Peters and Eckhart R{\"u}ther and Sebastiaan Engelborghs and Ellis Niemantsverdriet and {De Roeck}, {Ellen Elisa} and Magda Tsolaki and Yvonne Freund-Levi and Peter Johannsen and Rik Vandenberghe and Alberto Lle{\'o} and Daniel Alcolea and Frisoni, {Giovanni B} and Samantha Galluzzi and Flavio Nobili and Silvia Morbelli and Alexander Drzezga and Mira Didic and {van Berckel}, {Bart N} and Eric Salmon and Christine Bastin and Solene Dauby and Isabel Santana and In{\^e}s Baldeiras and {de Mendon{\c c}a}, Alexandre and Dina Silva and Anders Wallin and Arto Nordlund and Coloma, {Preciosa M} and Angelika Wientzek and Myriam Alexander and Novak, {Gerald P} and Gordon, {Mark Forrest} and Wallin, {{\AA}sa K} and Harald Hampel and Hilkka Soininen and Sanna-Kaisa Herukka and Philip Scheltens and Verhey, {Frans R} and Visser, {Pieter Jelle} and {Alzheimer{\textquoteright}s Disease Neuroimaging Initiative (ADNI)}",

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AU - Bos, Isabelle

AU - Vos, Stephanie J

AU - Frölich, Lutz

AU - Kornhuber, Johannes

AU - Wiltfang, Jens

AU - Maier, Wolfgang

AU - Peters, Oliver

AU - Rüther, Eckhart

AU - Engelborghs, Sebastiaan

AU - Niemantsverdriet, Ellis

AU - De Roeck, Ellen Elisa

AU - Tsolaki, Magda

AU - Freund-Levi, Yvonne

AU - Johannsen, Peter

AU - Vandenberghe, Rik

AU - Lleó, Alberto

AU - Alcolea, Daniel

AU - Frisoni, Giovanni B

AU - Galluzzi, Samantha

AU - Nobili, Flavio

AU - Morbelli, Silvia

AU - Drzezga, Alexander

AU - Didic, Mira

AU - van Berckel, Bart N

AU - Salmon, Eric

AU - Bastin, Christine

AU - Dauby, Solene

AU - Santana, Isabel

AU - Baldeiras, Inês

AU - de Mendonça, Alexandre

AU - Silva, Dina

AU - Wallin, Anders

AU - Nordlund, Arto

AU - Coloma, Preciosa M

AU - Wientzek, Angelika

AU - Alexander, Myriam

AU - Novak, Gerald P

AU - Gordon, Mark Forrest

AU - Wallin, Åsa K

AU - Hampel, Harald

AU - Soininen, Hilkka

AU - Herukka, Sanna-Kaisa

AU - Scheltens, Philip

AU - Verhey, Frans R

AU - Visser, Pieter Jelle

AU - Alzheimer’s Disease Neuroimaging Initiative (ADNI)

PY - 2017/8

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N2 - We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.

AB - We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.

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KW - Alzheimer Disease

KW - Biomarkers

KW - Cognition

KW - Cognitive Dysfunction

KW - Depression

KW - Disease Progression

KW - Female

KW - Humans

KW - Hypercholesterolemia

KW - Male

KW - Middle Aged

KW - Obesity

KW - Proportional Hazards Models

KW - Risk Factors

KW - Journal Article

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DO - 10.1016/j.neurobiolaging.2017.03.034

M3 - Journal article

C2 - 28482212

SN - 0197-4580

VL - 56

SP - 33

EP - 40

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

Abstract

Keywords

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