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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The estrogen hypothesis of schizophrenia implicates glucose metabolism: association study in three independent samples

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  1. Mutations in Danish patients with long QT syndrome and the identification of a large founder family with p.F29L in KCNH2

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  2. Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes

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  3. Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients

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  4. Dominant optic atrophy in Denmark - report of 15 novel mutations in OPA1, using a strategy with a detection rate of 90%

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  1. Cross-trait assortative mating is widespread and inflates genetic correlation estimates

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  2. Structural basis of organic cation transporter-3 inhibition

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  3. The population genomic legacy of the second plague pandemic

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  4. Is the CYP2D6 Genotype Associated with Antipsychotic-Induced Weight Gain?

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  5. A saturated map of common genetic variants associated with human height

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Schizophrenia is a highly heritable complex psychiatric disorder with an underlying pathophysiology that is still not well understood. Metaanalyses of schizophrenia linkage studies indicate numerous but rather large disease-associated genomic regions, whereas accumulating gene- and protein expression studies have indicated an equally large set of candidate genes that only partially overlap linkage genes. A thorough assessment, beyond the resolution of current GWA studies, of the disease risk conferred by the numerous schizophrenia candidate genes is a daunting and presently not feasible task. We undertook these challenges by using an established clinical paradigm, the estrogen hypothesis of schizophrenia, as the criterion to select candidates among the numerous genes experimentally implicated in schizophrenia. Bioinformatic tools were used to build and priorities the signaling networks implicated by the candidate genes resulting from the estrogen selection. We identified ten candidate genes using this approach that are all active in glucose metabolism and particularly in the glycolysis. Thus, we tested the hypothesis that variants of the glycolytic genes are associated with schizophrenia or at least with gender-associated aspects of the illness.
Original languageEnglish
JournalB M C Medical Genetics
Volume9
Pages (from-to)39
ISSN1471-2350
DOIs
Publication statusPublished - 2008

    Research areas

  • Adult, Blood Glucose, Case-Control Studies, Estrogens, Female, Gene Expression, Gene Frequency, Genetic Linkage, Genetic Markers, Genetic Predisposition to Disease, Glycolysis, Haplotypes, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Schizophrenia

ID: 36765441