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The EORTC CAT Core-The computer adaptive version of the EORTC QLQ-C30 questionnaire

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  • Morten Aa Petersen
  • Neil K Aaronson
  • Juan I Arraras
  • Wei-Chu Chie
  • Thierry Conroy
  • Anna Costantini
  • Linda Dirven
  • Peter Fayers
  • Eva-Maria Gamper
  • Johannes M Giesinger
  • Esther J J Habets
  • Eva Hammerlid
  • Jorunn Helbostad
  • Marianne J Hjermstad
  • Bernhard Holzner
  • Colin Johnson
  • Georg Kemmler
  • Madeleine T King
  • Stein Kaasa
  • Jon H Loge
  • Jaap C Reijneveld
  • Susanne Singer
  • Martin J B Taphoorn
  • Lise H Thamsborg
  • Krzysztof A Tomaszewski
  • Galina Velikova
  • Irma M Verdonck-de Leeuw
  • Teresa Young
  • Mogens Groenvold
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BACKGROUND: To optimise measurement precision, relevance to patients and flexibility, patient-reported outcome measures (PROMs) should ideally be adapted to the individual patient/study while retaining direct comparability of scores across patients/studies. This is achievable using item banks and computerised adaptive tests (CATs). The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) is one of the most widely used PROMs in cancer research and clinical practice. Here we provide an overview of the research program to develop CAT versions of the QLQ-C30's 14 functional and symptom domains.

METHODS: The EORTC Quality of Life Group's strategy for developing CAT item banks consists of: literature search to identify potential candidate items; formulation of new items compatible with the QLQ-C30 item style; expert evaluations and patient interviews; field-testing and psychometric analyses, including factor analysis, item response theory calibration and simulation of measurement properties. In addition, software for setting up, running and scoring CAT has been developed.

RESULTS: Across eight rounds of data collections, 9782 patients were recruited from 12 countries for the field-testing. The four phases of development resulted in a total of 260 unique items across the 14 domains. Each item bank consists of 7-34 items. Psychometric evaluations indicated higher measurement precision and increased statistical power of the CAT measures compared to the QLQ-C30 scales. Using CAT, sample size requirements may be reduced by approximately 20-35% on average without loss of power.

CONCLUSIONS: The EORTC CAT Core represents a more precise, powerful and flexible measurement system than the QLQ-C30. It is currently being validated in a large independent, international sample of cancer patients.

Original languageEnglish
JournalEuropean journal of cancer (Oxford, England : 1990)
Pages (from-to)8-16
Number of pages9
Publication statusPublished - Sep 2018

ID: 55594715