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The effects of CGRP in vascular tissue - Classical vasodilation, shadowed effects and systemic dilemmas

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  1. CGRP in rat mesenteric artery and vein - receptor expression, CGRP presence and potential roles

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  2. Gasotransmitters and the immune system: Mode of action and novel therapeutic targets

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  3. Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX

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  1. Vancouver Declaration II on Global Headache Patient Advocacy 2019

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  2. Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion

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  3. CGRP in rat mesenteric artery and vein - receptor expression, CGRP presence and potential roles

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Cellular distribution of PACAP-38 and PACAP receptors in the rat brain: Relation to migraine activated regions

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Vascular tissue consists of endothelial cells, vasoactive smooth muscle cells and perivascular nerves. The perivascular sensory neuropeptide CGRP has demonstrated potent vasodilatory effects in any arterial vasculature examined so far, and a local protective CGRP-circuit of sensory nerve terminal CGRP release and smooth muscle cell CGRP action is evident. The significant vasodilatory effect has shadowed multiple other effects of CGRP in the vascular tissue and we therefore thoroughly review vascular actions of CGRP on endothelial cells, vascular smooth muscle cells and perivascular nerve terminals. The actions beyond vasodilation includes neuronal re-uptake and neuromodulation, angiogenic, proliferative and antiproliferative, pro- and anti-inflammatory actions which vary depending on the target cell and anatomical location. In addition to the classical perivascular nerve-smooth muscle CGRP circuit, we review existing evidence for a shadowed endothelial autocrine pathway for CGRP. Finally, we discuss the impact of local and systemic actions of CGRP in vascular regulation and protection from hypertensive and ischemic heart conditions with special focus on therapeutic CGRP agonists and antagonists.

Original languageEnglish
JournalEuropean Journal of Pharmacology
Volume881
Pages (from-to)173205
Number of pages12
ISSN0014-2999
DOIs
Publication statusPublished - 2020

Bibliographical note

Copyright © 2020 Elsevier B.V. All rights reserved.

    Research areas

  • CGRP, Endothelial cells, Heart, Ischemic heart, Vascular effects, Vascular smooth muscle cells

ID: 59932515