The effect of salicylazosulphapyridine (sulphasalazine) on male fertility. A review

A Giwercman, N E Skakkebaek


Salicylazosulfapyridine (SASP), a drug used in the treatment of inflammatory bowel diseases, has been reported to depress the fertility in males. Therefore, some authors have proposed SASP as a new lead in the search for a contraceptive for men. Based on a review of the literature, our conclusion is that SASP taken in tolerable doses has not sufficient antifertility effect. Additionally, the drug has too serious and too many side effects to be accepted as a contraceptive. However, the effect on male fertility of other sulfa drugs and related compounds remains to be investigated.

Original languageEnglish
JournalInternational Journal of Andrology
Issue number1
Pages (from-to)38-52
Number of pages15
Publication statusPublished - Feb 1986
Externally publishedYes


  • Acrosome/drug effects
  • Animals
  • Bulbourethral Glands/drug effects
  • Chemical Phenomena
  • Chemistry
  • Contraceptive Agents, Male/administration & dosage
  • Contraceptives, Oral
  • Disease Models, Animal
  • Drug Interactions
  • Fertility/drug effects
  • Folic Acid/metabolism
  • Hormones/metabolism
  • Humans
  • Male
  • Sulfasalazine/administration & dosage
  • Testis/drug effects


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