The effect of RAAS blockade on markers of renal tubular damage in diabetic nephropathy: u-NGAL, u-KIM1 and u-LFABP

Stine Nielsen; Kasper Rossing; Georg Hess; Dietmar Zdunek; Berit R Jensen; Hans-Henrik Parving; Peter Rossing

doi:10.3109/00365513.2011.645055

The effect of RAAS blockade on markers of renal tubular damage in diabetic nephropathy: u-NGAL, u-KIM1 and u-LFABP

Stine Nielsen, Kasper Rossing, Georg Hess, Dietmar Zdunek, Berit R Jensen, Hans-Henrik Parving, Peter Rossing

21 Citations (Scopus)

Abstract

Blockade of the renin-angiotensin-aldosterone system (RAAS) affects both the glomerulus and tubules. We aimed to investigate the effect of irbesartan on the tubular markers: urinary (u) neutrophil gelatinase associated protein (NGAL), Kidney injury molecule 1 (KIM1) and liver-fatty acid-binding protein (LFABP).

Original language	English
Journal	Scandinavian Journal of Clinical & Laboratory Investigation
Volume	72
Issue number	2
Pages (from-to)	137-42
Number of pages	6
ISSN	0036-5513
DOIs	https://doi.org/10.3109/00365513.2011.645055
Publication status	Published - 2012

Keywords

Acute-Phase Proteins
Aged
Diabetic Nephropathies
Enzyme-Linked Immunosorbent Assay
Fatty Acid-Binding Proteins
Female
Humans
Kidney Tubules
Lipocalins
Male
Membrane Glycoproteins
Middle Aged
Proto-Oncogene Proteins
Receptors, Virus
Renin-Angiotensin System

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10.3109/00365513.2011.645055

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abstract = "Blockade of the renin-angiotensin-aldosterone system (RAAS) affects both the glomerulus and tubules. We aimed to investigate the effect of irbesartan on the tubular markers: urinary (u) neutrophil gelatinase associated protein (NGAL), Kidney injury molecule 1 (KIM1) and liver-fatty acid-binding protein (LFABP).",

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AU - Hess, Georg

AU - Zdunek, Dietmar

AU - Jensen, Berit R

AU - Parving, Hans-Henrik

AU - Rossing, Peter

PY - 2012

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AB - Blockade of the renin-angiotensin-aldosterone system (RAAS) affects both the glomerulus and tubules. We aimed to investigate the effect of irbesartan on the tubular markers: urinary (u) neutrophil gelatinase associated protein (NGAL), Kidney injury molecule 1 (KIM1) and liver-fatty acid-binding protein (LFABP).

KW - Acute-Phase Proteins

KW - Aged

KW - Diabetic Nephropathies

KW - Enzyme-Linked Immunosorbent Assay

KW - Fatty Acid-Binding Proteins

KW - Female

KW - Humans

KW - Kidney Tubules

KW - Lipocalins

KW - Male

KW - Membrane Glycoproteins

KW - Middle Aged

KW - Proto-Oncogene Proteins

KW - Receptors, Virus

KW - Renin-Angiotensin System

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DO - 10.3109/00365513.2011.645055

M3 - Journal article

C2 - 22268365

SN - 0036-5513

VL - 72

SP - 137

EP - 142

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

IS - 2

ER -

The effect of RAAS blockade on markers of renal tubular damage in diabetic nephropathy: u-NGAL, u-KIM1 and u-LFABP

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Keywords

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