TY - JOUR
T1 - The effect of postoperative gemcitabine on overall survival in patients with resected pancreatic cancer
T2 - A nationwide population-based Danish register study
AU - Skau Rasmussen, Louise
AU - Vittrup, Benny
AU - Ladekarl, Morten
AU - Pfeiffer, Per
AU - Karen Yilmaz, Mette
AU - Østergaard Poulsen, Laurids
AU - Østerlind, Kell
AU - Palnæs Hansen, Carsten
AU - Bau Mortensen, Michael
AU - Viborg Mortensen, Frank
AU - Sall, Mogens
AU - Detlefsen, Sönke
AU - Bøgsted, Martin
AU - Wilki Fristrup, Claus
PY - 2019/6
Y1 - 2019/6
N2 - BACKGROUND: Adjuvant chemotherapy following curative resection is the standard treatment for pancreatic adenocarcinoma (PC). Randomized clinical trials using gemcitabine have shown a median overall survival (mOS) of 2 years and a 5-year survival rate of 15-20%. However, the effect of gemcitabine outside these trials is less clear. We examined the effect of postoperative gemcitabine on survival in an unselected cohort of patients receiving curative resection for PC in Denmark during a five-year period.MATERIAL AND METHODS: From 1 May 2011 to 30 April 2016, 731 patients treated with curative resection were identified in the Danish Pancreatic Cancer Database (DPCD). Thirty patients died within 10 weeks postoperatively; 78 received other regimens or preoperative chemotherapy and were excluded. Of the remaining 623 patients, the chemotherapy (CT) group (n = 409, 66%) received gemcitabine within 10 weeks after resection, whereas the non-chemotherapy (NCT) group (n = 214, 34%) did not receive CT within 10 weeks.RESULTS: CT patients were slightly younger than NCT patients but did not otherwise differ in baseline characteristics. The CT group showed a mOS of 24 months (95% CI; 21-27) and a 5-year survival rate of 22% (95% CI; 17-27); the NCT group had a mOS of 22 months (95% CI; 16-26, p = .27) and a 5-year survival rate of 26% (95% CI; 19-34, p = .66). Most patients (415/623) had lymph node metastases. Of these patients, those in the CT group (n = 280) had significantly longer mOS [20 months (95% CI; 18-24)] than those in the NCT group (n = 135) [14 months (95% CI; 11-17)].CONCLUSIONS: In this national Danish cohort of PC patients undergoing resection between 2011 and 2016, the survival after postoperative gemcitabine was similar to that reported in previous clinical trials. However, the survival advantage of postoperative gemcitabine was limited to patients with lymph node metastases.
AB - BACKGROUND: Adjuvant chemotherapy following curative resection is the standard treatment for pancreatic adenocarcinoma (PC). Randomized clinical trials using gemcitabine have shown a median overall survival (mOS) of 2 years and a 5-year survival rate of 15-20%. However, the effect of gemcitabine outside these trials is less clear. We examined the effect of postoperative gemcitabine on survival in an unselected cohort of patients receiving curative resection for PC in Denmark during a five-year period.MATERIAL AND METHODS: From 1 May 2011 to 30 April 2016, 731 patients treated with curative resection were identified in the Danish Pancreatic Cancer Database (DPCD). Thirty patients died within 10 weeks postoperatively; 78 received other regimens or preoperative chemotherapy and were excluded. Of the remaining 623 patients, the chemotherapy (CT) group (n = 409, 66%) received gemcitabine within 10 weeks after resection, whereas the non-chemotherapy (NCT) group (n = 214, 34%) did not receive CT within 10 weeks.RESULTS: CT patients were slightly younger than NCT patients but did not otherwise differ in baseline characteristics. The CT group showed a mOS of 24 months (95% CI; 21-27) and a 5-year survival rate of 22% (95% CI; 17-27); the NCT group had a mOS of 22 months (95% CI; 16-26, p = .27) and a 5-year survival rate of 26% (95% CI; 19-34, p = .66). Most patients (415/623) had lymph node metastases. Of these patients, those in the CT group (n = 280) had significantly longer mOS [20 months (95% CI; 18-24)] than those in the NCT group (n = 135) [14 months (95% CI; 11-17)].CONCLUSIONS: In this national Danish cohort of PC patients undergoing resection between 2011 and 2016, the survival after postoperative gemcitabine was similar to that reported in previous clinical trials. However, the survival advantage of postoperative gemcitabine was limited to patients with lymph node metastases.
KW - Adenocarcinoma/pathology
KW - Adult
KW - Aged
KW - Antimetabolites, Antineoplastic/therapeutic use
KW - Denmark/epidemiology
KW - Deoxycytidine/analogs & derivatives
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Middle Aged
KW - Pancreatectomy/adverse effects
KW - Pancreatic Neoplasms/pathology
KW - Postoperative Complications/drug therapy
KW - Prognosis
KW - Prospective Studies
KW - Survival Rate
U2 - 10.1080/0284186X.2019.1581374
DO - 10.1080/0284186X.2019.1581374
M3 - Journal article
C2 - 30905248
SN - 0284-186X
VL - 58
SP - 864
EP - 871
JO - Acta oncologica
JF - Acta oncologica
IS - 6
ER -