TY - JOUR
T1 - The effect of physical exercise on cerebral blood flow in Alzheimer's disease
AU - van der Kleij, Lisa A
AU - Petersen, Esben T
AU - Siebner, Hartwig R
AU - Hendrikse, Jeroen
AU - Frederiksen, Kristian S
AU - Sobol, Nanna A
AU - Hasselbalch, Steen G
AU - Garde, Ellen
PY - 2018
Y1 - 2018
N2 - In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to moderate Alzheimer's disease. Fifty-one patients were randomized to either usual care or moderate-to-high intensity aerobic exercise for 16 weeks. Exercise had no consistent effect on whole brain or regional cerebral blood flow. Sixteen weeks of exercise are, therefore, not sufficient to produce a consistent increase in cerebral blood flow in a relatively small sample of Alzheimer's patients.
AB - In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to moderate Alzheimer's disease. Fifty-one patients were randomized to either usual care or moderate-to-high intensity aerobic exercise for 16 weeks. Exercise had no consistent effect on whole brain or regional cerebral blood flow. Sixteen weeks of exercise are, therefore, not sufficient to produce a consistent increase in cerebral blood flow in a relatively small sample of Alzheimer's patients.
U2 - 10.1016/j.nicl.2018.09.003
DO - 10.1016/j.nicl.2018.09.003
M3 - Journal article
C2 - 30211001
SN - 2213-1582
VL - 20
SP - 650
EP - 654
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
ER -