The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects

Shigehiko Ogoh; Kohei Sato; James P Fisher; Thomas Seifert; Morten Overgaard; Niels H Secher

doi:10.1111/j.1475-097X.2011.01040.x

The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects

Shigehiko Ogoh, Kohei Sato, James P Fisher, Thomas Seifert, Morten Overgaard, Niels H Secher

81 Citations (Scopus)

Abstract

Sympathetic regulation of the cerebral circulation remains controversial. Although intravenous phenylephrine (PE) infusion reduces the near-infrared spectroscopy (NIRS)-determined measure of frontal lobe oxygenation (S(c) O(2) ) and increases middle cerebral artery mean blood velocity (MCA V(mean) ), suggesting α-adrenergic-mediated cerebral vasoconstriction, this remains unconfirmed by evaluation of arterial and venous cerebral blood flow.

Original language	English
Journal	Clinical Physiology and Functional Imaging
Volume	31
Issue number	6
Pages (from-to)	445-51
Number of pages	7
ISSN	1475-0961
DOIs	https://doi.org/10.1111/j.1475-097X.2011.01040.x
Publication status	Published - 2011

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10.1111/j.1475-097X.2011.01040.x

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title = "The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects",

abstract = "Sympathetic regulation of the cerebral circulation remains controversial. Although intravenous phenylephrine (PE) infusion reduces the near-infrared spectroscopy (NIRS)-determined measure of frontal lobe oxygenation (S(c) O(2) ) and increases middle cerebral artery mean blood velocity (MCA V(mean) ), suggesting α-adrenergic-mediated cerebral vasoconstriction, this remains unconfirmed by evaluation of arterial and venous cerebral blood flow.",

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AU - Seifert, Thomas

AU - Overgaard, Morten

AU - Secher, Niels H

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AB - Sympathetic regulation of the cerebral circulation remains controversial. Although intravenous phenylephrine (PE) infusion reduces the near-infrared spectroscopy (NIRS)-determined measure of frontal lobe oxygenation (S(c) O(2) ) and increases middle cerebral artery mean blood velocity (MCA V(mean) ), suggesting α-adrenergic-mediated cerebral vasoconstriction, this remains unconfirmed by evaluation of arterial and venous cerebral blood flow.

U2 - 10.1111/j.1475-097X.2011.01040.x

DO - 10.1111/j.1475-097X.2011.01040.x

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VL - 31

SP - 445

EP - 451

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

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ER -

The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects

Abstract

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