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The effect of oral testosterone on serum TBG levels in alcoholic cirrhotic men

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@article{b564d733dffa4589a547231c19a1fc27,
title = "The effect of oral testosterone on serum TBG levels in alcoholic cirrhotic men",
abstract = "Seventy-three euthyroid male patients with alcoholic cirrhosis of the liver were randomly allocated to oral testosterone (200 mg t.i.d.) or placebo and followed for up to 36 months. Triiodothyronine (T3), tetraiodothyronine (T4), thyroxine binding globulin (TBG) and T4/TBG ratio were determined before entry and during follow-up. No significant differences were observed before entry or during follow-up between the two treatment groups. T3, T4 and T4/TBG ratio did not change significantly during follow-up, while TBG concentrations decreased (P less than 0.05). Using a multivariate test, it is demonstrated that testosterone treatment significantly reduced TBG concentrations in cirrhotic men with preserved liver function, like normal men, but not in patients with moderate liver dysfunction. The lack of effect of testosterone in patients with more advanced cirrhosis may be due to a decreased function of sex hormone receptors in their liver.",
keywords = "Administration, Oral, Adult, Aged, Humans, Liver, Liver Cirrhosis, Alcoholic, Male, Middle Aged, Receptors, Cell Surface, Testosterone, Thyroxine, Thyroxine-Binding Proteins, Triiodothyronine",
author = "U Becker and C Gluud and Patrick Bennett",
year = "1988",
month = "8",
language = "English",
volume = "8",
pages = "219--24",
journal = "Liver",
issn = "0106-9543",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - The effect of oral testosterone on serum TBG levels in alcoholic cirrhotic men

AU - Becker, U

AU - Gluud, C

AU - Bennett, Patrick

PY - 1988/8

Y1 - 1988/8

N2 - Seventy-three euthyroid male patients with alcoholic cirrhosis of the liver were randomly allocated to oral testosterone (200 mg t.i.d.) or placebo and followed for up to 36 months. Triiodothyronine (T3), tetraiodothyronine (T4), thyroxine binding globulin (TBG) and T4/TBG ratio were determined before entry and during follow-up. No significant differences were observed before entry or during follow-up between the two treatment groups. T3, T4 and T4/TBG ratio did not change significantly during follow-up, while TBG concentrations decreased (P less than 0.05). Using a multivariate test, it is demonstrated that testosterone treatment significantly reduced TBG concentrations in cirrhotic men with preserved liver function, like normal men, but not in patients with moderate liver dysfunction. The lack of effect of testosterone in patients with more advanced cirrhosis may be due to a decreased function of sex hormone receptors in their liver.

AB - Seventy-three euthyroid male patients with alcoholic cirrhosis of the liver were randomly allocated to oral testosterone (200 mg t.i.d.) or placebo and followed for up to 36 months. Triiodothyronine (T3), tetraiodothyronine (T4), thyroxine binding globulin (TBG) and T4/TBG ratio were determined before entry and during follow-up. No significant differences were observed before entry or during follow-up between the two treatment groups. T3, T4 and T4/TBG ratio did not change significantly during follow-up, while TBG concentrations decreased (P less than 0.05). Using a multivariate test, it is demonstrated that testosterone treatment significantly reduced TBG concentrations in cirrhotic men with preserved liver function, like normal men, but not in patients with moderate liver dysfunction. The lack of effect of testosterone in patients with more advanced cirrhosis may be due to a decreased function of sex hormone receptors in their liver.

KW - Administration, Oral

KW - Adult

KW - Aged

KW - Humans

KW - Liver

KW - Liver Cirrhosis, Alcoholic

KW - Male

KW - Middle Aged

KW - Receptors, Cell Surface

KW - Testosterone

KW - Thyroxine

KW - Thyroxine-Binding Proteins

KW - Triiodothyronine

M3 - Journal article

VL - 8

SP - 219

EP - 224

JO - Liver

JF - Liver

SN - 0106-9543

IS - 4

ER -

ID: 38930504