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The effect of non-esterified long-chain fatty acids on blood flow and thermogenesis in brown adipose tissue in the young dog

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@article{2bb5cbd4af084e9b97b6e73a6b3c34fb,
title = "The effect of non-esterified long-chain fatty acids on blood flow and thermogenesis in brown adipose tissue in the young dog",
abstract = "In vitro experiments have demonstrated that increasing the molar ratio of extracellular non-esterified fatty acids (NEFA) to albumin stimulates thermogenesis in brown adipocytes. To test these results, in vivo blood flow and local temperature were measured in perirenal brown adipose tissue (BAT) in puppies during thermogenesis induced by increasing the plasma NEFA: albumin ratio by injection of intralipid and heparin. Plasma NEFA concentration increased to 1.5 mmol X 1-I and plasma NEFA:albumin ratio to 4. Concomitantly, the whole body oxygen consumption rose on average about 100{\%} above baseline level. Plasma noradrenaline concentration increased about three-fold and plasma adrenaline concentration about six-fold. The BAT temperature increased by an average of 0.9 degrees C. However, since BAT blood flow was simultaneously reduced by about 50{\%}, it can be calculated that the local heat production was also reduced. Consequently, the increase in whole body oxygen consumption was not due to stimulation of BAT thermogenesis. It is concluded that in vivo assessment of BAT thermogenesis requires concomitant measurements of both local BAT temperature and blood flow.",
keywords = "Adipose Tissue, Adipose Tissue, Brown, Animals, Blood Glucose, Blood Pressure, Body Temperature Regulation, Catecholamines, Dogs, Fat Emulsions, Intravenous, Fatty Acids, Nonesterified, Heparin, Oxygen Consumption, Pulse, Regional Blood Flow, Serum Albumin",
author = "A Astrup and J B{\"u}low and Christensen, {N J}",
year = "1985",
month = "5",
doi = "10.1111/j.1748-1716.1985.tb07634.x",
language = "English",
volume = "124",
pages = "81--5",
journal = "Acta Physiologica Scandinavica, Supplement",
issn = "0302-2994",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - The effect of non-esterified long-chain fatty acids on blood flow and thermogenesis in brown adipose tissue in the young dog

AU - Astrup, A

AU - Bülow, J

AU - Christensen, N J

PY - 1985/5

Y1 - 1985/5

N2 - In vitro experiments have demonstrated that increasing the molar ratio of extracellular non-esterified fatty acids (NEFA) to albumin stimulates thermogenesis in brown adipocytes. To test these results, in vivo blood flow and local temperature were measured in perirenal brown adipose tissue (BAT) in puppies during thermogenesis induced by increasing the plasma NEFA: albumin ratio by injection of intralipid and heparin. Plasma NEFA concentration increased to 1.5 mmol X 1-I and plasma NEFA:albumin ratio to 4. Concomitantly, the whole body oxygen consumption rose on average about 100% above baseline level. Plasma noradrenaline concentration increased about three-fold and plasma adrenaline concentration about six-fold. The BAT temperature increased by an average of 0.9 degrees C. However, since BAT blood flow was simultaneously reduced by about 50%, it can be calculated that the local heat production was also reduced. Consequently, the increase in whole body oxygen consumption was not due to stimulation of BAT thermogenesis. It is concluded that in vivo assessment of BAT thermogenesis requires concomitant measurements of both local BAT temperature and blood flow.

AB - In vitro experiments have demonstrated that increasing the molar ratio of extracellular non-esterified fatty acids (NEFA) to albumin stimulates thermogenesis in brown adipocytes. To test these results, in vivo blood flow and local temperature were measured in perirenal brown adipose tissue (BAT) in puppies during thermogenesis induced by increasing the plasma NEFA: albumin ratio by injection of intralipid and heparin. Plasma NEFA concentration increased to 1.5 mmol X 1-I and plasma NEFA:albumin ratio to 4. Concomitantly, the whole body oxygen consumption rose on average about 100% above baseline level. Plasma noradrenaline concentration increased about three-fold and plasma adrenaline concentration about six-fold. The BAT temperature increased by an average of 0.9 degrees C. However, since BAT blood flow was simultaneously reduced by about 50%, it can be calculated that the local heat production was also reduced. Consequently, the increase in whole body oxygen consumption was not due to stimulation of BAT thermogenesis. It is concluded that in vivo assessment of BAT thermogenesis requires concomitant measurements of both local BAT temperature and blood flow.

KW - Adipose Tissue

KW - Adipose Tissue, Brown

KW - Animals

KW - Blood Glucose

KW - Blood Pressure

KW - Body Temperature Regulation

KW - Catecholamines

KW - Dogs

KW - Fat Emulsions, Intravenous

KW - Fatty Acids, Nonesterified

KW - Heparin

KW - Oxygen Consumption

KW - Pulse

KW - Regional Blood Flow

KW - Serum Albumin

U2 - 10.1111/j.1748-1716.1985.tb07634.x

DO - 10.1111/j.1748-1716.1985.tb07634.x

M3 - Journal article

VL - 124

SP - 81

EP - 85

JO - Acta Physiologica Scandinavica, Supplement

JF - Acta Physiologica Scandinavica, Supplement

SN - 0302-2994

IS - 1

ER -

ID: 39027812